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Response to letter regarding article, humoral and cellular response to the third COVID-19 vaccination in patients with inborn errors of immunity (IEI) or mannan-binding lectin (MBL) deficiency-A prospective controlled open-label trial: correspondence.
Wien Klin Wochenschr
December 2024
Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus.
Proc Natl Acad Sci U S A
July 2021
Department of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark;
Nanotechnology enables investigations of single biomacromolecules, but technical challenges have limited the application in liquid biopsies, for example, blood plasma. Nonetheless, tools to characterize single molecular species in such samples represent a significant unmet need with the increasing appreciation of the physiological importance of protein structural changes at nanometer scale. Mannose-binding lectin (MBL) is an oligomeric plasma protein and part of the innate immune system through its ability to activate complement.
View Article and Find Full Text PDFSterile Inflammation of Brain, due to Activation of Innate Immunity, as a Culprit in Psychiatric Disorders.
Front Psychiatry
February 2018
Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
Evidence has accumulated that the occurrence of psychiatric disorders is related to chronic inflammation. In support of this linkage, changes in the levels of circulating pro-inflammatory cytokines and chemokines in the peripheral blood (PB) of psychiatric patients as well as correlations between chronic inflammatory processes and psychiatric disorders have been described. Furthermore, an inflammatory process known as "sterile inflammation" when initiated directly in brain tissue may trigger the onset of psychoses.
View Article and Find Full Text PDFTesticular expression of SP-A, SP-D and MBL-A is positively regulated by testosterone and modulated by lipopolysaccharide.
Immunobiology
September 2016
Department of Innate Immunity, National Institute for Research in Reproductive Health (NIRRH), Indian Council of Medical Research (ICMR), Parel, Mumbai 400 012, India. Electronic address:
Pattern recognition proteins viz., Surfactant Protein-A (SP-A), Surfactant Protein-D (SP-D) and Mannan Binding Lectin-A (MBL-A) regulate inflammatory immune responses. In view of their plausible contribution to immune privilege in testis, the present study explored their expression and regulation in murine testis.
View Article and Find Full Text PDFMarkers for the progression of IgA nephropathy.
J Nephrol
August 2016
Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague 2, Czech Republic.
We have summarized the latest findings on markers for progression of immunoglobulin A (IgA) nephropathy (IgAN), the most common primary glomerulonephritis with a high prevalence among end-stage renal disease (ESRD) patients. The clinical predictors of renal outcome in IgAN nephropathy, such as proteinuria, hypertension, and decreased estimated glomerular filtration rate (eGFR) at the time of the diagnosis, are well known. The Oxford classification of IgAN identified four types of histological lesions (known as the MEST score) associated with the development of ESRD and/or a 50 % reduction in eGFR.
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