Silica-bound benzoyl chloride mediated the solid-phase synthesis of 4H-3,1-benzoxazin-4-ones.

Beilstein J Org Chem

Chemistry Department, University of Guilan, P.O. Box 41335-19141, Rasht, Iran.

Published: April 2009

The solid-phase synthesis of 4H-3,1-benzoxazin-4-ones was achieved using silica-bound benzoyl chloride (SBBC) as dehydrating agent in reaction with 2-acylaminobenzoic acids. The silica-grafted reagent (SBBC) was simply recovered after reaction and reused several times.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686276PMC
http://dx.doi.org/10.3762/bjoc.5.13DOI Listing

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