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Enantiospecific synthesis of [2.2]paracyclophane-4-thiol and derivatives. | LitMetric

Enantiospecific synthesis of [2.2]paracyclophane-4-thiol and derivatives.

Beilstein J Org Chem

Institute of Fundamental Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand.

Published: March 2009

AI Article Synopsis

  • The paper outlines a straightforward method for producing a chiral compound, [2.2]paracyclophane-4-thiol, using a specific chiral sulfoxide.
  • It highlights a significant achievement in synthetic chemistry by reporting the first successful creation of an enantiomerically enriched planar chiral benzothiazole.
  • The research emphasizes the importance of stereochemistry in synthesizing complex organic molecules with specific orientations.

Article Abstract

This paper describes a simple route to enantiomerically enriched [2.2]paracyclophane-4-thiol via the stereospecific introduction of a chiral sulfoxide to the [2.2]paracyclophane skeleton. The first synthesis of an enantiomerically enriched planar chiral benzothiazole is also reported.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686273PMC
http://dx.doi.org/10.3762/bjoc.5.9DOI Listing

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