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Do-Nothing Prebiotic Chemistry: Chemical Kinetics as a Window into Prebiotic Plausibility.

Acc Chem Res

January 2025

Astrophysics Group, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.

ConspectusOrigin of Life research is a fast growing field of study with each year bringing new breakthroughs. Recent discoveries include novel syntheses of life's building blocks, mechanisms of activation and interaction between molecules, and newly identified environments that provide promising conditions for these syntheses and mechanisms. Even with these new findings, firmly grounded in rigorous laboratory experiments, researchers often find themselves uncertain about how to apply them.

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Hot Jupiters are among the best-studied exoplanets, but it is still poorly understood how their chemical composition and cloud properties vary with longitude. Theoretical models predict that clouds may condense on the nightside and that molecular abundances can be driven out of equilibrium by zonal winds. Here we report a phase-resolved emission spectrum of the hot Jupiter WASP-43b measured from 5 μm to 12 μm with the JWST's Mid-Infrared Instrument.

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Solvent constraints for biopolymer folding and evolution in extraterrestrial environments.

Proc Natl Acad Sci U S A

May 2024

Laboratorio de Fisiología de Proteínas, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires CP1428, Argentina.

We propose that spontaneous folding and molecular evolution of biopolymers are two universal aspects that must concur for life to happen. These aspects are fundamentally related to the chemical composition of biopolymers and crucially depend on the solvent in which they are embedded. We show that molecular information theory and energy landscape theory allow us to explore the limits that solvents impose on biopolymer existence.

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Article Synopsis
  • The term "biosignature" is crucial in astrobiology, linking observations to possible biological causes, but its definitions vary across scientific communities.
  • There are concerns that current definitions may overstate certainty and create confusion, especially since the distinction between life and non-life is not always clear.
  • The authors propose that scientists should be cautious with the term, define it explicitly, and use a checklist for evaluating biosignature claims to enhance communication and understanding in the field.
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Essential insights on the characterization and quality of a detectable biosphere are gained by analyzing the effects of its environmental parameters. We compiled environmental and biological properties of the Phanerozoic Eon from various published data sets and conducted a correlation analysis to assess variations in parameters relevant to the habitability of Earth's biosphere. We showed that environmental parameters such as oxygen, global average surface temperatures, runoff rates and carbon dioxide are interrelated and play a key role in the changes of biomass and biodiversity.

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