Background: Previous studies have suggested that impaired fetal and childhood growth are associated with an increased risk of schizophrenia, but the association of pre-adult growth with non-clinical psychotic symptoms (psychosis-like symptoms) in children is not known.
Aims: To explore the associations of body size at birth and age 7.5 years with childhood psychosis-like symptoms.
Method: Prospective cohort of children followed up from birth to age 12: the ALSPAC cohort.
Results: Data on 6000 singleton infants born after 37 weeks of gestation. A one standard deviation increase in birth weight was associated with an 18% reduction in the risk of definite psychosis-like symptoms after adjusting for age and gestation (Odds ratio (OR) = 0.82, 95% CI = 0.73-0.92, P = 0.001). This association was partly confounded by maternal anthropometry, smoking during pregnancy, socioeconomic status and IQ. A similar association was seen for birth length and psychosis-like symptoms, which disappeared after controlling for birth weight. There was little evidence for an association of 7-year height or adiposity with psychosis-like symptoms.
Conclusions: Measures of impaired fetal, but not childhood, growth are associated with an increased risk of psychosis-like symptoms in 12-year-olds.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802530 | PMC |
| http://dx.doi.org/10.1192/bjp.bp.108.051730 | DOI Listing |
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