Before the etiology of Lyme borreliosis became known, its human manifestations were most often treated with penicillin. Treatment was mostly successful, in spite of the fact that lower doses were generally used, but the doses were given with shorter intervals. Lately, other antibiotics have been tried, more or less successfully, but there is still no consensus as to which--if any--antibiotic is superior to others, or if one manifestation of the infection is better treated than another with a particular antibiotic.
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