A series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB(2) receptor-dependent G-protein activities were determined using the [(35)S]GTPgammaS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB(2) receptor agonist activity, the most potent ligands being the 2-(Me(2)N)-phenyl substituted derivatives, which were also full agonists at the CB(2)-receptor.
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Synthesis of Pyrazolo[1,5-]pyridinyl, Pyrazolo[1,5-]quinolinyl, and Pyrazolo[5,1-]isoquinolinyl Sulfonyl Fluorides via a [3 + 2] Annulation.
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School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, P. R. China.
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Department of Chemistry, Texas A&M University, P.O. Box 30012, College Station, Texas, 77842-3012, USA.
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Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering , Shaanxi Normal University, No.620 West Chang'an Avenue , Xi'an 710119 , China.
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Department of Chemistry, University of California, Berkeley, California 94720, United States.
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