We evaluated the use of multilayer human amniotic membrane (HAM) as a grafting material for the repair of mid-palate oronasal fistulas in seven Berlin minipigs. After two weeks, three animals had the fistulas repaired with multilayered HAM grafts, three had them repaired with a collagen-based dermal substitute (INTEGRA((R)), Integra Life Sciences, Plainsboro, NJ, USA), and one fistula was left untreated to serve as a control. Grafts were interposed between the oral and nasal mucosa, traversing the fistulas. After healing for 40 days, the pigs were killed for clinical, histological, and immunohistochemical examination. Two of the three fistulas closed with HAM were successful, the diameter of the third was reduced in size, and there was no change in the diameter of the fistula in the control. This study shows successful closure of oronasal fistulas in minipigs using interposed grafts of cryopreserved HAM, and offers promise as a simple and effective technique for tension-free closure of such fistulas.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bjoms.2009.04.025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
FTY720P-treated macrophages in PEG-4MAL hydrogels promote oral wound healing.
Cytotherapy
November 2024
Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia, USA; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA; Department of Otolaryngology, Children's Healthcare of Atlanta, Atlanta, Georgia, USA. Electronic address:
Background Aims: Oral wound healing involves hemostasis, inflammation, proliferation and tissue remodeling. The oral cavity is a complex wound healing environment because of the presence of saliva, a high bacterial burden and ongoing physical trauma from eating. The inflammatory component of wound healing balances the polarization of macrophages in healing tissues between M1 inflammatory macrophages and M2 anti-inflammatory macrophages.
View Article and Find Full Text PDFEndoscopic-assisted Maxillectomy and Fibular Flap Reconstruction: A Scarless Facial Approach With Novel Reconstruction and Operative Techniques Avoiding Facial Skin Incision.
J Craniofac Surg
December 2024
Department of Plastic and Reconstructive Surgery, Jikei University School of Medicine.
The facial approach remains a challenge in maxillectomy and reconstruction. Various surgical approaches have been developed to improve cosmetic outcomes. The authors herein present a novel approach for endoscopic-assisted maxillectomy with minimal facial incision and endoscopic-assisted vascularized fibular osteomyocutaneous flap (VFOF) reconstruction.
View Article and Find Full Text PDFASSESSING ORONASAL FISTULA RATES: MINIPLATE AS EXTERNAL FIXATOR VS ANTERIOR NASAL SPINE PLATING FOR PALATAL FRACTURES.
J Ayub Med Coll Abbottabad
November 2024
Akbar Niazi Teaching Hospital, Islamabad-Pakistan.
Background: Palate, a midface bone, shapes the face and supports buttresses. Palatine process of maxilla and horizontal plate of palatine bone constitute it. Palatal bone is thicker anteriorly and laterally than posteriorly and centrally.
View Article and Find Full Text PDFOutcomes of Palatal Fistula Closure with Tongue Flap Using a Parachute Technique.
Cleft Palate Craniofac J
November 2024
Department of Plastic Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objective: To evaluate the efficacy of tongue flaps in closing large palatal fistulas secondary to cleft palate repair in terms of functionality, esthetics, and donor site morbidity.
Design: Tertiary academic center.
Setting: We report our 8-year surgical experience with tongue flaps, with our parachute suture technique in flap inset, and not using tongue fixation methods or feeding tubes.
Dental Treatment Needs Among 16-Year-Old Patients with Cleft Lip and Palate: An Observational Study in Western Norway.
Cleft Palate Craniofac J
November 2024
Oral Health Centre of Expertise/Western Norway, Bergen, Norway.
Article Synopsis
- The study evaluated dental alignment and occlusion in 1019 patients with Cleft Lip and/or Palate (CL/P) at age 16, focusing on the need for future dental treatment.
- About one-third of the patients required further dental care, with complete CL/P cases showing a greater need compared to isolated cleft conditions.
- Key factors like missing teeth, oronasal fistula, and being male were linked to worse dental outcomes and increased treatment needs.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!