Extramammary Paget's disease (EMPD) of the scrotum is extremely rare. Most cases are found on the vulva or anus. It is generally accepted that EMPD is associated with an underlying carcinoma in situ. The lesion is located deep in between the dermal to epidermal layer. EMPD must be differentiated from benign papulosquamous disease, squamous cell carcinoma and melanoma. It can be managed by local excision and reconstruction with a skin graft or skin flap. Radiation and topical chemotherapy have also been used as alternative treatment strategies and are effective for local control.
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Extramammary Paget's Disease.
Br J Dermatol
December 2024
Department of Dermatology, The First Hospital of China Medical University, Shenyang, China; Key laboratory of Immunodermatology, Ministry of Health and Education, Shenyang, China.
Triple-negative ectopic breast cancer of the male scrotum: a case report.
Front Oncol
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Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Male breast cancer represents only 1% of all breast malignancies, with ectopic breast cancer in men being even rarer and highly prone to diagnostic challenges. Extramammary Paget's disease (EMPD), a rare cutaneous tumor with non-specific clinical symptoms, is susceptible to misdiagnosis. This report discusses the case of an older male patient who presented with a scrotal mass, later identified as ectopic breast invasive adenocarcinoma upon pathological examination post-lesion excision.
View Article and Find Full Text PDFNuances of cytokeratin-7 immunohistochemistry interpretation during Mohs micrographic surgery for anogenital extramammary Paget's disease.
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Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
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Department of General Surgery, University College of Medical Sciences and GTB Hospital, Delhi, India.
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College of Medicine, Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Extramammary Paget disease is an uncommon cutaneous malignancy that primarily affects areas rich in apocrine glands. Here, we aim to present an 84-year-old woman with a distinctive perianal neoplastic process comprised of conventional Paget disease with an intertwined in-situ glandular component. Rare foci of glands embedded in pools of mucin were also identified in the most recent excision, consistent with mucinous adenocarcinoma.
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