[Clinical and therapeutic results of a retrospective study about 62 cases of epithelial ovarian carcinomas].

Aim: To report retrospectively the therapeutic results and prognostic factors of epithelial ovarian carcinomas throughout a serie of 62 patients treated between 1993 and 2002.

Methods: Patients were treated with primary surgery classified as optimal (complete), sub-optimal or minimal. Adjuvant ciplatin based poly chemotherapy (6 cycles) was indicated in FIGO stage Ic or more. Patients with minimal surgery received 3 or 4 cycles of chemotherapy followed by an interval debulking surgery. Overall survival was calculated according to Kaplan-Meier and univariate analysis done by the Log-Rank test for the following factors: age group, surgical excision, stage, histological type and presence or not of ascitis at diagnosis.

Results: Fifty five patients were operated. The excision was optimal, suboptimal and minimal in respectively 19.3%, 33.8% and 40.3% of the cases. Adjuvant or neoadjuvant chemotherapy was given to 50 patients (93.5%). Interval debulking surgery was complete in 7 among 13 patients. At the first evaluation, 14/58 patients were in complete response. The 3 and 5 years overall survival rates were respectively of 25% and 13%. Advanced stage was the only pejorative prognostic factor (P= 0.0002).

Conclusion: Incomplete surgery (minimal) and chemotherapy without taxanes based chemotherapy were associated with poor outcome in our patients. Our study confirmed the importance of disease stage as a prognostic factor.