It's as simple as that: An in situ prepared chiral catalyst from the commercially available compounds Ti(OiPr)(4) and (R)-binol catalyzes the highly enantioselective ring-opening of meso-aziridines 1 with anilines 2 and furnishes valuable chiral 1,2-diamines 3 in high yields and up to 99 % ee.(R)-binol=(R)-2,2'-dihydroxy-1,1'-binaphthyl.
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