AI Article Synopsis
- Peritumoral brain edema in glioblastoma patients significantly impacts neurological symptoms and is debated as a prognostic factor.
- A study of 110 glioblastoma patients assessed the effect of pre-treatment edema, classified as minor or major, on overall survival using MRI scans.
- Findings indicate that major edema correlates with shorter survival rates compared to minor edema, suggesting it should be considered in treatment planning and future clinical trials.
Article Abstract
Background: Peritumoral brain edema in glioblastoma patients is a frequently encountered phenomenon that strongly contributes to neurological signs and symptoms. The role of peritumoral edema as a prognostic factor is controversial.
Materials And Methods: This multi-centre clinical retrospective study included 110 patients with histologically proven glioblastoma. The prognostic impact on overall survival of pre-treatment peritumoral edema detected on MRI-scans was evaluated. All patients had preoperative MRI, surgery, histology, and received standard treatment regimens. Edema on MRI-scans was classified as minor (<1 cm), and major (>1 cm).
Results: Our results confirm that peritumoral edema on preoperative MRI is an independent prognostic factor in addition to postoperative Karnofsky performance score (KPS), age, and type of tumor resection. Patients with major edema had significant shorter overall survival compared to patients with minor edema.
Conclusion: This easily applicable early radiological characterization may contribute to a more subgroup oriented treatment in glioblastoma patients for future trials, as well as in clinical routine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1468-1331.2009.02613.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!