Purpose: We compared hexaminolevulinate (HAL) blue light cystoscopy (BLC) with standard white light cystoscopy (WLC) in the diagnosis of noninvasive bladder tumors (NIBT) and analyzed the efficiency of blue light transurethral resection of the bladder (BL-TURB).
Materials And Methods: WLC and BLC were performed in 64 cases. BL-TURB was applied for lesions that were detected only by BLC. Patients who received a diagnosis of NIBT were followed up after 18 weeks by WLC and BLC. The control group included the same number of consecutive patients with NIBT, diagnosed only by WLC and treated by WL-TURB.
Results: WLC correctly diagnosed 66.4%, with a 9.7% rate of false-positive results, while BLC diagnosed 95.7%, but had a 13.5% rate of false-positive results. The study group had a recurrence rate of 5.3% vs 23.2% in the control group.
Conclusions: HAL fluorescence cystoscopy is a valuable diagnostic method, with considerably improved accuracy. BL-TURB represents a superior treatment modality, with significant impact on the recurrence rate.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1089/end.2008.0574 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Low-cost and label-free blue light cystoscopy through digital staining of white light cystoscopy videos.
Commun Med (Lond)
December 2024
Vanderbilt University, Department of Biomedical Engineering, Nashville, TN, 37232, USA.
Background: Bladder cancer is the 10 most common malignancy and carries the highest treatment cost among all cancers. The elevated cost stems from its high recurrence rate, which necessitates frequent surveillance. White light cystoscopy (WLC), the standard of care surveillance tool to examine the bladder for lesions, has limited sensitivity for early-stage bladder cancer.
View Article and Find Full Text PDF[Modern optical non-invasive technologies in diagnostics of urological diseases. Literature review. Part I].
Urologiia
November 2024
GBUZ City Hospital Saint Luka, Saint Petersburg, Russia.
The effects of the interaction of optical radiation and biological tissues underlie various optical diagnostics technologies, including laser Doppler flowmetry, diffuse reflection spectroscopy, fluorescent spectroscopy, photodynamic diagnostics (fluorescent cystoscopy), confocal microscopy, optical coherence tomography, etc. The efficiency of these technologies is the subject of study in various fields of medicine, such as dermatology and ophthalmology, anesthesiology and cardiac surgery, in the diagnosis of malignant tumors and others. In the first part of our review, the available data on the feasibility of using laser Doppler flowmetry and diffuse reflection spectroscopy as a diagnostic tool in urological practice are reviewed and systematized.
View Article and Find Full Text PDFIntravesical hexyl-aminolevulinate used to detect upper tract carcinoma in situ during surveillance ureteroscopy: A case report and review.
Urol Case Rep
September 2024
Mayo Clinic Department of Urology, 4500 San Pablo Rd S, Jacksonville, FL, 32224, USA.
Blue-light cystoscopy with intravesical hexyl-aminolevulinate has been shown to improve identification of bladder carcinoma. The application of photodynamic techniques in the upper tract has not been well studied. We present a patient with a patulous ureteral orifice allowing for dwelling of photodynamic reagent and cystoscopic evaluation of the distal ureter.
View Article and Find Full Text PDFLocation-specific diagnostic efficiency of photodynamic diagnosis-guided biopsy in bladder mapping biopsies.
Int J Urol
November 2024
Department of Urology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
Background: Photodynamic diagnosis (PDD)-assisted transurethral resection of bladder tumors (TURBT) has emerged as a promising complementary tool to white light (WL) cystoscopy, potentially improving cancer detection and replacing conventional mapping biopsies. This study aimed to investigate the diagnostic accuracy of PDD by anatomical locations in mapping biopsies through lesion-based analysis.
Methods: PDD and WL findings were prospectively recorded in 102 patients undergoing mapping biopsies and PDD-assisted TURBT using oral 5-aminolevulinic acid.
Intraoperative Fluorescent Ureter Visualization for Transvaginal High Uterosacral Ligament Suspension for Severe Pelvic Organ Prolapse.
Int Urogynecol J
July 2024
Department of Gynecology, Fondazione IRCCS San Gerardo Dei Tintori-University of Milano-Bicocca, Via Pergolesi 33, Monza, Italy.
Article Synopsis
- The study aimed to explore the use of intra-ureteric indocyanine green (ICG) and near-infrared fluorescence (NIRF) imaging for safely navigating the ureters during transvaginal surgeries for prolapse repair to minimize the risk of ureter injuries.
- The methodology involved using a cystoscope and ureteral catheter to identify the ureter, allowing for clear visualization through NIRF imaging before placing sutures in the ligaments.
- Results showed no complications during or after the procedure, suggesting that using ICG-NIRF imaging is an effective, low-cost method to enhance ureteral detection during challenging surgical situations.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!