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Serum Autotaxin Levels Predict Liver-Related Events in Patients With Primary Biliary Cholangitis: A Long-Term Multicenter Observational Study.
Clin Transl Gastroenterol
December 2024
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.
Article Synopsis
- A study explored the potential of serum autotaxin (ATX) as a predictor for liver-related events (LRE) in patients with primary biliary cholangitis (PBC).
- During a median follow-up of 9.7 years of 190 untreated patients, those with ATX levels ≥1.086 mg/L experienced significantly more LRE compared to those with lower levels (33.3% vs 3.6%).
- The research suggests that ATX is a strong independent predictor for LRE, outperforming existing markers, and aligns with findings from a separate validation cohort of PBC patients.
Modeling Protein-Glycan Interactions with HADDOCK.
J Chem Inf Model
October 2024
Bijvoet Centre for Biomolecular Research, Faculty of Science - Chemistry, Utrecht University, Padualaan 8, Utrecht 3584CH, The Netherlands.
The term glycan refers to a broad category of molecules composed of monosaccharide units linked to each other in a variety of ways, whose structural diversity is related to different functions in living organisms. Among others, glycans are recognized by proteins with the aim of carrying information and for signaling purposes. Determining the three-dimensional structures of protein-glycan complexes is essential both for the understanding of the mechanisms glycans are involved in and for applications such as drug design.
View Article and Find Full Text PDFInsights Into Glycobiology and the Protein-Glycan Interactome Using Glycan Microarray Technologies.
Mol Cell Proteomics
November 2024
Department of Surgery Beth Israel Deaconess Medical Center, National Center for Functional Glycomics (NCFG), Harvard Medical School, Boston, Massachusetts, USA. Electronic address:
Glycans linked to proteins and lipids and also occurring in free forms have many functions, and these are partly elicited through specific interactions with glycan-binding proteins (GBPs). These include lectins, adhesins, toxins, hemagglutinins, growth factors, and enzymes, but antibodies can also bind glycans. While humans and other animals generate a vast repertoire of GBPs and different glycans in their glycomes, other organisms, including phage, microbes, protozoans, fungi, and plants also express glycans and GBPs, and these can also interact with their host glycans.
View Article and Find Full Text PDFCharacterization of Ssc, an -acetylgalactosamine-containing surface polysaccharide.
J Bacteriol
May 2024
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Unlabelled: Whole genome sequencing has revealed that the genome of possesses an uncharacterized 5-gene operon (SAOUHSC_00088-00092 in strain 8325 genome) that encodes factors with functions related to polysaccharide biosynthesis and export, indicating the existence of a new extracellular polysaccharide species. We designate this locus as for staphylococcal surface carbohydrate. We found that the genes were weakly expressed and highly repressed by the global regulator MgrA.
View Article and Find Full Text PDFN-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.
Clin Chem Lab Med
July 2024
Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Objectives: Multiple myeloma (MM) is a plasma cell malignancy characterized by a monoclonal expansion of plasma cells that secrete a characteristic M-protein. This M-protein is crucial for diagnosis and monitoring of MM in the blood of patients. Recent evidence has emerged suggesting that N-glycosylation of the M-protein variable (Fab) region contributes to M-protein pathogenicity, and that it is a risk factor for disease progression of plasma cell disorders.
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