AI Article Synopsis
- A noncoding mitochondrial RNA with an inverted repeat (IR) has been found covalently linked to the 5' end of the mitochondrial 16S RNA in human cells.
- This RNA transcript, characterized by a stem-loop structure, is present in proliferating human cells but absent in resting cells.
- Additionally, two antisense mitochondrial transcripts with similar stem-loop structures are expressed in normal cells but significantly down-regulated in various tumor cell lines, highlighting their potential role in distinguishing normal cells from cancerous ones and offering insights into cancer biology and diagnostics.
Article Abstract
We reported the presence in human cells of a noncoding mitochondrial RNA that contains an inverted repeat (IR) of 815 nucleotides (nt) covalently linked to the 5' end of the mitochondrial 16S RNA (16S mtrRNA). The transcript contains a stem-loop structure and is expressed in human proliferating cells but not in resting cells. Here, we demonstrate that, in addition to this transcript, normal human proliferating cells in culture express 2 antisense mitochondrial transcripts. These transcripts also contain stem-loop structures but strikingly they are down-regulated in tumor cell lines and tumor cells present in 17 different tumor types. The differential expression of these transcripts distinguishes normal from tumor cells and might contribute a unique vision on cancer biology and diagnostics.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695051 | PMC |
| http://dx.doi.org/10.1073/pnas.0903086106 | DOI Listing |
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