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Metastatic Malignant Melanoma of Brain: A Rare Case Report.
Asian J Neurosurg
December 2024
Department of Neurosurgery, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.
Malignant melanoma is third most common cause of brain metastasis after lung and breast cancer. Most patients with brain metastases from malignant melanoma are diagnosed after treatment for known extracranial metastases and have a poor outcome despite various local and systemic therapeutic approaches. Here we discuss an unusual case of a 61-year-old male patient who presented with a brain metastasis as the initial disease presentation and the presumed primary lesion was later found in the gastrointestinal tract and the scalp.
View Article and Find Full Text PDFPlumage polymorphism in the black sparrowhawk (Accipiter melanoleucus) is strongly associated with expression level of agouti signalling protein.
J Hered
November 2024
Department of Molecular and Cell Biology, University of Cape Town, South Africa.
Article Synopsis
- The study investigates the causes of plumage color variations in black sparrowhawks, focusing on the role of specific genes related to melanin production.
- It finds that adult color differences are linked to how eumelanin is distributed in their feathers, with no significant mutations in key genes (MC1R, ASIP) discovered for adult color morphs.
- For juvenile plumage, variations are attributed to levels of eumelanin and pheomelanin, showcasing a complex relationship with ASIP expression that challenges existing theories on how melanin types are produced.
A Report of Two Cases of Tuberculosis With Bronchial Anthracofibrosis: Diagnostic Challenges and Therapeutic Approaches.
Cureus
October 2024
Pulmonology and Critical Care, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
A clinical entity that was reported less than ten years ago, bronchial anthracofibrosis is marked by multifocal bronchial lumen constriction and anthracotic coloring of the bronchial mucosa. There is various etiology associated with "black bronchoscopy". A 47-year-old woman with no known co-morbidities reported having a three-month history of coughing up sputum.
View Article and Find Full Text PDF[Metastatic breast melanoma in a man: Case report].
Rev Med Inst Mex Seguro Soc
March 2024
Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Hospital Regional de Monterrey, Departamento de Medicina Interna. Monterrey, Nuevo León, México.
Background: Malignant melanoma is a skin neoplasm that typically does not invade the breast, making its spread to the breast tissue in a male patient uncommon. When it metastasizes to the breast, it can present as a palpable mass or even be asymptomatic. Ultrasound allows for the detection of round hypoechoic lesions, while mammography detects well-defined nodules with increased density.
View Article and Find Full Text PDFDesign and synthesis of a novel isoleucine-derived Schiff base ligand: Structural characterization, molecular docking, and biological activity evaluation.
Int J Health Sci (Qassim)
January 2024
Department of Clinical Laboratory Sciences, College of Applied Medical Science, Jouf University, Aljouf, Saudi Arabia.
Article Synopsis
- Schiff bases are important chemical compounds used in various fields such as catalysis, pigments, and have biological activities like antifungal and antibacterial effects.
- A unique Schiff base ligand was created by combining specific organic compounds, and its complexes were characterized through multiple scientific techniques, demonstrating their structural properties.
- The resulting metal complexes showed enhanced antibacterial and antiproliferative effects, particularly against breast cancer cells, indicating their potential as new therapeutic agents, though more research is necessary to explore their mechanisms.
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