Near infrared (NIR) absorbing Au-Au(2)S nanoparticles were modified with surfactants of different hydrocarbon chain lengths to allow loading of anticancer drug, cisplatin. The interfacial interactions and surfactant chain length effects on drug loading, optical properties and cytotoxicity were discussed in this work. Short-chain surfactants were oriented closer to the surface normal and were adsorbed at higher densities. Surface modification also changed the optical properties of the particles. Notably, particles modified with short-chain surfactants exhibited a red shift, whereas particles modified with long-chain surfactants showed a blue shift. The in vitro cytotoxicity of drug-loaded surface-modified particles was dependent on the surfactants' chain length. Significant cytotoxicity was observed for 1 mg/ml of drug-loaded particles using surfactants with the shortest chain length. After NIR triggered drug release, the released Pt compounds were observed to be cytotoxic, while remaining nanoparticles did not exhibit any cytotoxicity. Also, the released Pt compounds upon NIR irradiation of drug-loaded particles were observed to be more toxic and had a different molecular structure from cisplatin.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10856-009-3779-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oligoethylene Phosphoramidate-based Kinase Inhibitor Prodrugs - Solubility, Enzyme Inhibition, and Hydrolysis.
Chemistry
January 2025
Ulm University: Universitat Ulm, Organic Chemistry III, Albert-Einstein-Allee 11, 89081, Ulm, GERMANY.
The efficiency of kinase inhibiting cancer therapeutics is often limited by their poor solubility in water. PEGylation is one possible strategy to improve the solubility of the drug, however, means to cleave these after reaching the target is important to make use of the therapeutic effects of the native drug. Moreover, the length of the PEG chains will have an effect on the solubility and binding.
View Article and Find Full Text PDFSustanon suppresses spermatogenesis and increases cell death.
Transl Androl Urol
December 2024
Department of Pathology, Pediatric and Perinatal Pathology, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: Anabolic-androgenic steroids (AAS) are synthetic derivatives of testosterone. Sustanon, dissolved in peanut oil, is an AAS used by athletes to build muscle mass. This study aims to examine the effects of Sustanon on male reproductive health.
View Article and Find Full Text PDFPlanar solid phase extraction for chlorinated paraffin analysis - irradiation chamber for standardized derivatization on planar thin-layers.
J Chromatogr A
January 2025
Institute of Food Chemistry, Department of Food Chemistry and Analytical Chemistry, University of Hohenheim, Garbenstraße 28, 70599 Stuttgart, Germany. Electronic address:
As an established analytical method, high-performance thin-layer chromatography (HPTLC) offers powerful capabilities. This study focused on its application to analyze chlorinated paraffins (CP) by planar solid phase extraction (pSPE). Based on previous work, an irradiation chamber was developed to investigate the derivatization process on planar thin-layers and ensure a robust and reproducible analysis.
View Article and Find Full Text PDFPolydopamine-assisted ion-mediated hyaluronic acid grafting for effective construction of hemocompatible platform with cancer cell recognition.
Int J Biol Macromol
January 2025
MOE Key Laboratory of Bio-Intelligent Manufacturing, Liaoning Key Laboratory of Molecular Recognition and Imaging, School of Bioengineering, Dalian University of Technology, Dalian 116023, PR China. Electronic address:
Surfaces capable of specific biomolecule recognition are essential for cancer theranostics, biosensing, and tissue engineering. However, current grafting methods, critical for dictating the recognition efficiency and biocompatibility of biomaterials, especially hydrophilic polymers, struggle to balance high grafting density with ease of implementation. In pursuit of a simple, effective, and versatile solution, we introduced a polydopamine (PDA)-assisted Ca-mediated grafting strategy using hyaluronic acid (HA) as a model material.
View Article and Find Full Text PDFThe structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix.
Matrix Biol
January 2025
Manchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, M13 9PL, United Kingdom. Electronic address:
Pentraxin-3 (PTX3) is an octameric protein, comprised of eight identical protomers, that has diverse functions in reproductive biology, innate immunity and cancer. PTX3 interacts with the large polysaccharide hyaluronan (HA) to which heavy chains (HCs) of the inter-α-inhibitor (IαI) family of proteoglycans are covalently attached, playing a key role in the (non-covalent) crosslinking of HC•HA complexes. These interactions stabilise the cumulus matrix, essential for ovulation and fertilisation in mammals, and are also implicated in the formation of pathogenic matrices in the context of viral lung infections.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!