Vivosorb is a new degradable membrane composed of poly(DL-lactide-epsilon-caprolactone) (PDLLCL). The aim of this study was to appraise its performance in guided bone regeneration procedures. In 192 rats a 5.0 mm defect was drilled in the mandibular angle. The defects were covered with a membrane (PDLLCL, collagen, or expanded polytetrafluoroethylene (ePTFE)) or left uncovered (control). Defect closure, mineralization and thickness of the new bone were assessed by means of transversal microradiography at three different time intervals (2, 4 and 12 weeks). The data were analysed using multiple regression analyses. The regression analyses showed significant effect modification between time and collagen and time and ePTFE for mineralization of the newly formed bone. For defect closure and bone thickness all membrane-treated groups showed effect modification between time and membrane; these effects were more significant and larger in the collagen and ePTFE groups. In the non-treated controls no effect modification was observed. The membrane groups showed significantly better results than the control groups. The ePTFE and collagen membranes performed equally well and better than the PDLLCL membrane during this experiment. It was concluded that a PDLLCL membrane is not suitable for clinical application in its current form.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijom.2009.04.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Objectives: The aim of the study was to investigate the caries-preventive effect of fluoride-free toothpastes, containing either herbal agents or (nano-)hydroxyapatite.
Methods: Bovine dentin specimens each having a sound [ST], and a demineralized area [DT]) were prepared and randomly allocated to eleven groups (n=187). Treatments during pH-cycling (28 days;6x120min demineralization/day) were brushing 2x/day with: 0ppm F- [NaF0], 500ppm F- [NaF500], 1,100ppm F- [NaF1100], grape seed extract [GSE], (nano-)hydroxyapatite [nHA, HA], melaleuca oil [MO1, MO2, MO-CU] and propolis + myrrh [PM1, PM2] containing dentifrices.
Paving the way for the use of Statherin-Derived Peptide (StN15) to control caries through acquired pellicle and biofilm microbiome engineering: Proof-of-concept in vitro/in vivo studies.
Arch Oral Biol
December 2024
Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil. Electronic address:
Objective: This proof-of-concept sequence of in vivo/in vitro studies aimed to unveil the role of acquired enamel pellicle (AEP) engineering with statherin-derived peptide (StN15) on the AEP protein profile, enamel biofilm microbiome in vivo and on enamel demineralization in vitro.
Design: In vivo studies, 10 volunteers, in 2 independent experiments (2 days each), rinsed (10 mL,1 min) with: deionized water (negative control) or 1.88 × 10 M StN15.
Resveratrol alters oral biofilm in vitro and in vivo.
J Dent
January 2025
Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Al. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo 17012-901, Brazil. Electronic address:
Objective: To evaluate the ability of resveratrol to reduce dental caries in vitro and in vivo.
Methods: In part 1, a microcosm biofilm protocol was employed. One hundred twenty-six bovine enamel specimens were treated with: Resveratrol (50, 100, 200, 400 µg/mL), Phosphate buffered saline (negative control), Dimethyl sulfoxide (negative control) and 0.
Effectiveness of New Isomalt-Containing Toothpaste Formulations in Preventing Dental Caries: A Microbial Study.
Dent J (Basel)
September 2024
Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78712, USA.
Article Synopsis
- This study analyzed how effective Isomalt-containing toothpaste is in preventing dental caries compared to traditional fluoride toothpaste.
- Human dental enamel slabs were tested under different conditions, using various toothpaste formulations over a week-long period with plaque exposure.
- Results showed that toothpaste with 10% Isomalt, fluoride, and CPC was significantly more effective at reducing demineralization and caries development than toothpaste containing only fluoride.
Influence of irradiated dentin, biofilm and different artificial saliva formulations on root dentin demineralization.
Heliyon
August 2024
Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
The aim of this study was evaluated the influence of radiation as well as of new formulations of artificial saliva on the development of root dentin lesions. Bovine root samples were divided into: irradiated (70 Gy) dentin or not; the type of biofilm (from irradiated patient-experimental or non-irradiated patient-control) and the type of artificial saliva (for the condition irradiated dentin/biofilm from irradiated patient): Control Artificial Saliva (inorganic); Control Saliva + 1 mg/ml hemoglobin; Control Saliva +0.1 mg/ml cystatin; Control Saliva + hemoglobin + cystatin; Bioextra (positive control) and deionized water (DiW, negative control) (n = 12/group).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!