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Cureus
December 2024
Research, Nibbot International, Mexico City, MEX.
Background: Autism spectrum disorder (ASD) is a heterogeneous neurobiological condition characterized by behavioral problems and delayed neurodevelopment. Although transcranial magnetic stimulation (TMS) has been proposed as an alternative treatment for patients with ASD because of its promising benefits in reducing repetitive behaviors and enhancing executive functions, the use of high-intensity pulses (Hi-TMS) appears to be related to the side effects of the therapy. Low-intensity TMS (Li-TMS) has been partially investigated, but it may have clinical effects on ASD and simultaneously increase treatment safety.
View Article and Find Full Text PDFRespir Med Case Rep
December 2024
Division of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO, USA.
Dendriform pulmonary ossification (DPO) is a rare condition characterized by mature bone formation in the lung. DPO has been linked to various conditions, but little is known about the link between DPO and hazardous airborne exposures. We queried research databases of military personnel evaluated for deployment-related respiratory diseases at two occupational pulmonary medicine clinics (Colorado, USA) for diagnoses of DPO, and summarized demographics, Gulf War military deployment history, medical history, and pulmonary function testing.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Fire safety in healthcare facilities is extremely important due to limited evacuation capacity of occupants. Therefore, poor fire safety precautions lead to more fatalities and financial losses. This study introduces an effective fire risk management approach for healthcare buildings utilizing an interval valued neutrosophic-fuzzy framework.
View Article and Find Full Text PDFUnlabelled: Transparent and accurate reporting in early phase dose-finding (EPDF) clinical trials is crucial for informing subsequent larger trials. The SPIRIT statement, designed for trial protocol content, does not adequately cover the distinctive features of EPDF trials. Recent findings indicate that the protocol contents in past EPDF trials frequently lacked completeness and clarity.
View Article and Find Full Text PDFUnlabelled: Early phase dose-finding (EPDF) trials are key in the development of novel therapies, with their findings directly informing subsequent clinical development phases and providing valuable insights for reverse translation. Comprehensive and transparent reporting of these studies is critical for their accurate and critical interpretation, which may improve and expedite therapeutic development. However, quality of reporting of design characteristics and results from EPDF trials is often variable and incomplete.
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