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Silica-exposed patients with silicosis show shorter telomeres than do unexposed individuals: a pilot study in a population in southeastern Brazil.
J Bras Pneumol
January 2025
. Departamento de Biologia Geral, Universidade Federal Fluminense, Niterói (RJ) Brasil.
Objective: Silicosis is a pneumoconiosis characterized by fibrosis of the lung parenchyma caused by the inhalation of silica particles. Silica dust inhalation is associated with inflammation and induction of oxidative stress in the lungs. This oxidative stress affects telomeres, which are short tandem DNA repeats that cap the end of linear chromosomes.
View Article and Find Full Text PDFAnalysis of Mortality and Life Expectancy Determinants Among 5,791 Deceased Pneumoconiosis Patients - Jiangsu Province, China, 2011-2023.
China CDC Wkly
December 2024
Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing City, Jiangsu Province, China.
Pneumoconiosis is the occupational disease with the highest proportion in China. This study conducted a retrospective analysis of 5,791 deceased pneumoconiosis patients. In this study, males comprised 93.
View Article and Find Full Text PDFRespiratory Diseases with High Occupational Fraction in Italy: Results from the Italian Hospital Discharge Registry (2010-2021).
Healthcare (Basel)
December 2024
Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian National Workers' Compensation Authority (INAIL), Via Stefano Gradi 55, 00143 Rome, Italy.
Objectives: Occupational respiratory diseases represent a major public health concern worldwide. This study analyses the hospitalization costs and characteristics of four major occupational respiratory diseases: malignant mesothelioma (MM), sinonasal cancer (SNC), pneumoconiosis (PN), and hypersensitivity pneumonitis (HP). The findings are situated within the context of Italy's population trends and healthcare system, offering insights into the economic and clinical burden of these diseases.
View Article and Find Full Text PDFToo Soon to Breathe Easy: Trends in Asbestosis Morbidity and Mortality in Wisconsin.
J Occup Environ Med
January 2025
From the Occupational Health Safety and Surveillance Program, Bureau of Environmental and Occupational Health, Wisconsin Department of Health Services, Madison, Wisconsin (P.D.C., K.E.M., K.K.S.M., C.R.M., S.B.); and Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin (P.D.C., K.K.S.M.).
Objectives: This study aimed to describe asbestosis morbidity and mortality in two statewide samples. We considered trends, demographic disparities, and excess mortality.
Methods: We assessed trends and demographic differences in asbestosis morbidity using hospital and emergency department (ED) visits.
Tripartite motif-containing 32 regulated by miR-6236-p5 inhibited silica-induced apoptosis of alveolar macrophages.
Toxicology
December 2024
Molecular Toxicology Laboratory of Sichuan Provincial Education office, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University Chengdu, 610041, China; West China Occupational Pneumoconiosis Cohort Study (WCOPCS) working group, Research Center for Prevention and Therapy of Occupational Disease, West China-PUMC C.C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China. Electronic address:
Apoptosis of alveolar macrophages (AMs) induced by silica is one of the crucial driving factors of silicosis inflammation and fibrosis. However, the mechanism of silica-induced AMs apoptosis remains unclear. In this study, transcriptome sequencing identified 11 differentially expressed (DE)-mRNAs enriched in the regulation of apoptotic signaling pathways in AMs treated with 250 μg/mL silica for 24 h, of which tripartite motif-containing 32 (Trim32) was the most significant and down-regulated.
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