AI Article Synopsis
- The study explored how Ginkgo biloba extract (EGb) influences VEGF expression following subarachnoid hemorrhage (SAH) in Wistar rats.
- Increased levels of VEGF mRNA and protein were observed in SAH and vehicle groups over time, indicating an enhanced response to the injury.
- EGb treatment further boosted VEGF expression, suggesting it may help protect against brain damage after SAH by increasing VEGF levels.
Article Abstract
The study aimed to investigate the effect of extract of Ginkgo biloba (EGb) on the expression of vascular endothelial growth factor (VEGF) after subarachnoid hemorrhage (SAH). Wistar rats were divided into non-SAH, SAH, vehicle, EGb1 (low-dose), and EGb2 (high-dose) groups. VEGF mRNA and VEGF protein were measured from brain tissues. The expressions of VEGF mRNA in SAH and vehicle groups were enhanced 24 and 72 hr after the establishment of SAH. Increased VEGF positive cells were found in the brain tissues in SAH and vehicle groups. The expressions of VEGF mRNA and VEGF protein were further increased by the pretreatment of EGb. We concluded that EGb exerts protective effects on secondary cerebral ischemic injury after SAH via the promotion of the expression of VEGF.
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| http://dx.doi.org/10.1080/00207450902815842 | DOI Listing |
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