AI Article Synopsis
- The study presents a Doppler optical coherence tomography (DOCT) system designed for high-speed imaging, capable of capturing cardiac dynamics in an embryo in vivo with a handheld scanner.
- This system operates at 1.3 µm wavelength and achieves a wide velocity dynamic range and high fidelity imaging by increasing the reference arm scanning rate.
- Using four different display modes, the DOCT effectively detects changes in velocity distribution, measures velocity gradients, and differentiates blood flow signals from cardiac wall movements during heart cycles.
Article Abstract
We previously reported a Doppler optical coherence tomography (DOCT) system design [1] for high-speed imaging with wide velocity dynamic range (up to 28.5 dB when acquiring 8 frames per second), operating at 1.3 m with a coherence length of 13.5 m. Using a developmental biology model (Xenopus laevis), here we test the DOCT system's ability to image cardiac dynamics in an embryo in vivo, with a simple hand-held scanner at 4 ~ 16 frames per second. In particular, we show that high fidelity DOCT movies can be obtained by increasing the reference arm scanning rate (~8 kHz). Utilizing a combination of four display modes (B-mode, color-Doppler, velocity variance, and Doppler spectrum), we show that DOCT can detect changes in velocity distribution during heart cycles, measure the velocity gradient in the embryo, and distinguish blood flow Doppler signal from heart wall motions.
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| http://dx.doi.org/10.1364/oe.11.001650 | DOI Listing |
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