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Closing the gaps in the access to quality-assured medicines for global health: The case for oxytocin for postpartum haemorrhage.
Expert Rev Clin Pharmacol
January 2025
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Introduction: Access to quality-assured medicines remains unequal between high-income and low-income countries. To bridge this gap, product development and supply in low- and middle-income countries (LMICs) should follow World Health Organization (WHO)'s policies and recommendations whilst aligning with international standards.
Areas Covered: We reviewed two cases on oxytocin access for postpartum hemorrhage (PPH), a condition that disproportionately affects mothers in low-income countries.
Routine vaginal examination to assess labor progress at 8 compared to 4 h after early amniotomy following Foley balloon ripening in the labor induction of nulliparas: A randomized trial.
Acta Obstet Gynecol Scand
December 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Article Synopsis
- * Conducted as a randomized controlled trial with 210 participants, results showed no significant difference in the amniotomy-to-delivery interval or maternal satisfaction between the two time frames.
- * However, the 8-hour examination group experienced a lower cesarean rate and was less likely to have scheduled examinations compared to the 4-hour group, indicating potential benefits to the longer waiting period.
Perspectives of midwives on the use of Kaligutim (local oxytocin) for induction of labour among pregnant women in the government hospitals in Tamale.
BMC Pregnancy Childbirth
August 2024
Department of Population and Reproductive Health, School of Public Health, University for Development Studies, P. O. Box 1883, Tamale, Northern Region, Ghana.
Background: The use of herbal medicine and/or its products is common throughout the world. In Tamale Metropolis, pregnant women frequently use local oxytocin to induce labour, as shown by the fact that 90% of midwives reported managing patients who used kaligutim (local oxytocin) to speed up labour. Early career midwives are also aware of this and have personally observed it being used by their clients.
View Article and Find Full Text PDFInpatient's, therapist's and staff's expectations regarding treatment and their effects on placebo response in the psychiatric ward - results from an add-on oxytocin RCT.
Psychopharmacology (Berl)
September 2024
Shalvata Mental Health Center, 13 Aliyat-Hanoar st, Hod-Hasharon, 4534708, Israel.
Objectives: Patient's and therapist's expectations are considered an important factor influencing placebo response in experimental and therapeutic settings. Nevertheless, the placebo effects of common neurological facilitators that promote treatment efficacy have not been explored. In the present study we examined the estimations of patients, therapists, and staff members, regarding their treatment type and assessed their influence on the facilitating effects of oxytocin.
View Article and Find Full Text PDFMedical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With ARFID.
Int J Eat Disord
November 2024
Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- ARFID (Avoidant/Restrictive Food Intake Disorder) is prevalent among youth with nutrition-related medical issues, and this study examines its medical comorbidities and nutritional markers compared to healthy controls.
- In the study of 100 youth with ARFID and 58 healthy controls, those with ARFID reported significantly higher instances of gastrointestinal (37% vs. 3%) and immune-mediated conditions (42% vs. 24%).
- Youth with ARFID also showed higher rates of elevated triglycerides (28% vs. 12%) and hs-CRP levels (17% vs. 4%), indicating potential cardiovascular risks potentially linked to their restricted diets.
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