Clarithromycin is a broad-spectrum macrolide antibacterial agent which is effective both in vitro and in vivo against the major pathogens responsible for respiratory tract infections. Clarithromycin's principal metabolite is 14-(R) hydroxyclarithromycin (14-OH-clarithromycin). The other metabolite, namely 14-(S) hydroxyclarithromycin is inactive. The purpose of this study was to show the hydroxylation of CLA at the 14 position to form the R and S epimers and to determine the metabolic ratio of 14ROHCLA/CLA and 14SOHCLA/CLA for understanding the metabolization. This study suggest that in healthy adults, the individual variations in therapeutic responses to clarithromycin can be assumed by taking the drug and its metabolites ratios. Clarithromycin and metabolites ratios increase during metabolization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF03191380 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associations between neonicotinoids and inflammation in US adults using hematological indices: NHANES 2015-2016.
Environ Epidemiol
February 2025
Department of Epidemiology and Biostatistics, University of Nevada Las Vegas, School of Public Health, Las Vegas, Nevada.
Background: Toxicological studies suggest neonicotinoids increase oxidative stress and inflammation, but few epidemiological studies have explored these effects.
Methods: National Health and Nutrition Examination Survey (NHANES) 2015-2016 data were used to estimate associations between neonicotinoid exposure and inflammatory markers, including the C-reactive protein-to-lymphocyte count ratio (CLR), monocyte-to-high-density lipoprotein ratio (MHR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) using linear and multinomial logistic regression models. Sex was evaluated as a potential modifier.
Degradation of myosmine by a novel bacterial strain Sphingopyxis sp. J-6 and its degradation pathways.
J Hazard Mater
December 2024
College of Tobacco Science, Henan Agricultural University, Zhengzhou 450002, China; National Tobacco Cultivation and Physiology and Biochemistry Research Center, Zhengzhou 450002, China; Key Laboratory for Tobacco Cultivation of Tobacco Industry, Zhengzhou 450002, China. Electronic address:
This study isolated a myosmine-degrading bacterial strain J-6 from tobacco-growing soil. The identification of this strain revealed it to be a new species within the genus Sphingopyxis. Analysis of the myosmine degradation products by HPLC, preparative HPLC, and UHPLC-MS/MS identified 8 metabolites, among which 3-pyridylacetic acid (3-PAA), 5-(3-pyridyl)tetrahydrofuranone-2 (PTHF), and 4-hydroxy-4-(3-pyridyl)butanoic acid (HPBA) were three novel metabolites that were not previously found in microbial degradation of tobacco alkaloids.
View Article and Find Full Text PDFResveratrol and β-hydroxy-β-methylbutyric acid supplementation promotes ileal development and digestive function by altering microbial community abundance and metabolites in Tibetan sheep.
Front Vet Sci
December 2024
College of Agriculture and Animal Husbandry, Qinghai University, Xining, China.
Introduction: The effects of resveratrol (RES) and β-hydroxy-β-methylbutyric acid (HMB) on phenotype, immunity, digestive enzyme activity and short-chain fatty acids (SCFAs) contents in ileum of Tibetan sheep were investigated.
Methods: A total of 120 two-month-old Tibetan sheep (15.5 ± 0.
Integrative analysis of the transcriptome, proteomics and metabolomics reveals key genes involved in the regulation of breast muscle metabolites in capons.
BMC Genomics
December 2024
Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Foshan University, Foshan, 528225, P.R. China.
Castration is widely used in poultry and livestock to enhance fat metabolism and improve the flavor, tenderness and juiciness of meat. However, the genetic regulatory mechanism underlying castration consequences have not been clarified. To investigate the key metabolites affecting the quality of capons and the key regulatory mechanisms, Qingyuan partridge roosters were subjected to castration.
View Article and Find Full Text PDFPathway mapping of exhaled volatile organic compounds associated with blood and ruminal fluid metabolites to describe the nutritional and metabolic status of lactating dairy cows.
J Dairy Sci
December 2024
Ruminant Nutrition and Emissions, Agroscope, 1700 Posieux, Switzerland. Electronic address:
Exhaled breath offers an interesting matrix of low invasive sampling of potentially relevant information about the organism's metabolism in the form of volatile organic compounds (VOC). The VOC can be exhaled by the ructus (Islam et al., 2023) or passed the blood-lung barrier for expiration through the lungs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!