Ann Plast Surg
Department of Plastic Surgery, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 443, Houston, TX, USA.
Published: June 2009
Despite the development of multiple cranial bone substitutes, calvarial reconstruction remains a significant challenge. Although autologous bone is preferred in many cases, its usefulness may be limited by difficulty with contouring, resorption, and donor site availability and morbidity. Alloplastic cranioplasties are also widely used with each material having its advantages and disadvantages. Computer-designed implants have the advantages of minimizing operative time for preparation, shaping, and insetting. We report our initial clinical experience in 6 patients with computer-designed, prefabricated polyetheretherketone implants, which may have significant advantages over other alloplastic materials in terms of strength, stiffness, durability, thermal conductivity, and radiographic translucency.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/SAP.0b013e318184abc7 | DOI Listing |
Adv Healthc Mater
February 2025
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, P. R. China.
Bone tissue engineering is a critical area of research focused on enhancing the regeneration of bone tissue, particularly in cases of complex defects. Despite inherent self-healing capabilities of bone, irregularly-shaped defects pose significant challenges for complete regeneration, thereby necessitating innovative therapeutic strategies. This study addresses these challenges by exploring the development of advanced tissue regeneration scaffolds.
View Article and Find Full Text PDFRegen Biomater
February 2025
Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Effective reconstruction of large bone defects, particularly in thickness, remains one of the major challenges in orthopedic and dental fields. We previously produced an -based industrial-scale GMP-grade recombinant human bone morphogenetic protein-2 (E-rhBMP-2) and showed that the combination of E-rhBMP-2 with beta-tricalcium phosphate (β-TCP/E-rhBMP-2) can effectively promote bone reconstruction. However, the limited mechanical strength and poor morphology retention of β-TCP granules are key points that need optimization to obtain more effective grafts and further expand its clinical applications.
View Article and Find Full Text PDFBiomed J
February 2025
Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807377, Taiwan; Department of Surgery, School of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807378, Taiwan. Electronic address:
Background: Autologous bone remains the gold standard for surgical bone reconstruction but presents clinical challenges like donor site complications and operational difficulties.
Method: We investigate the osteogenic effects of a newly designed, ceramic and collagen-based, submicron-processed Flexible Hydrated-Hardening Bone Graft (FHBG), using both murine and human mesenchymal stem cells. We also compare the efficacy and safety of FHBG with a commercially available (CA) graft in New Zealand white rabbits with cranial bone defects.
J Transl Med
February 2025
Department of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Formerly Tokyo Medical and Dental University, Tokyo, 113-8549, Japan.
Background: MicroRNAs (miRNAs) play a crucial role in cell differentiation through epigenetic regulation of gene expression. In human dental pulp cells, we have identified miRNA-27a being upregulated under inflammatory conditions. Here, we aimed to examine whether (i) overexpression of miRNA-27a in human dental pulp stem cells (hDPSCs) enhances their odonto/osteoblastic differentiation via Wnt and bone morphogenetic protein signaling; and (ii) hDPSCs overexpressing miRNA-27a promote new bone formation in vivo.
View Article and Find Full Text PDFJ Neurosurg Pediatr
February 2025
1Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Missouri.
Objective: Combined sagittal and unilateral coronal synostosis is an uncommon multisuture synostosis. The objective of this study was to describe patient demographics, characterize craniofacial morphology, and report surgical outcomes for patients with combined sagittal and unilateral coronal synostosis undergoing surgical repair.
Methods: This was a retrospective cohort study performed as a joint effort between two US pediatric tertiary care institutions.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.