AI Article Synopsis
- * Blastoid variant of mantle cell lymphoma (BV-MCL) is a rare and more aggressive type of MCL, identified by specific markers like CD20+, CD5+, and cyclin D1+.
- * The case discussed highlights a BV-MCL that originated in the skin, showcasing its unique immunophenotype and genetic translocation (t(11;14)).
Article Abstract
Mantle cell lymphoma (MCL) commonly involves extranodal sites, usually as a manifestation of disseminated disease. In rare cases, MCLs may arise as a primary tumor in the skin. Blastoid mantle cell lymphoma (BV-MCL) is a rare variant and has a more aggressive clinical course. The phenotype of BV-MCL is characterized as CD20+, CD5+, cyclin D1+, CD23-, and CD10-. Interphase fluorescence in situ hybridization shows a characteristic t(11;14) fusion pattern. We report a case of a BV-MCL arising in skin as primary cutaneous MCL with the characteristic immunophenotype and translocation.
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| http://dx.doi.org/10.1097/DAD.0b013e31819d845a | DOI Listing |
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