Objective: To investigate the protective effect of estrogen against cyclophosphamide (CTX)-induced ovarian failure in female rats.
Methods: Sixty female Wistar rats (2-3 months old) were randomized into 4 groups to receive treatments with normal saline, CTX, estradiol (E2) or CTX+E2. Serum estradiol and follicle-stimulating hormone (FSH) concentrations were measured regularly in the 4 groups, and the weight of the ovary and uterus, follicle number and mean diameter of the follicles were compared.
Results: Compared with CTX+EE2 group, the CTX group showed significantly increased FSH levels and decreased EE2 levels (P<0.05). The weight of the ovary and uterus and follicle number were significantly lower in CTX group than in CTX+EE2 group (P<0.05). No obvious differences in the indexes were found between the control and CTX+E2 groups.
Conclusion: Estrogen administration provides protection against CTX-induced ovarian damage in rats.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Application of three statistical approaches to explore effects of dietary intake of multiple persistent organic pollutants on ER-positive breast cancer risk in the French E3N cohort.
Sci Rep
January 2025
Inserm, Gustave Roussy, Centre for Research in Epidemiology and Population Health (CESP), "Exposome, Heredity, Cancer, and Health" Team, Université Paris-Saclay, UVSQ, 12 Avenue Paul Vaillant Couturier, 94805, Villejuif, France.
Persistent organic pollutants (POPs) are a group of organic chemical compounds. Contradictory results have emerged in epidemiological studies attempting to elucidate their relationship with breast cancer risk. This study explored the relationship between dietary exposures to multiple POPs and ER-positive breast cancer risk in the French E3N cohort study, using three different approaches to handle multicollinearity among exposures.
View Article and Find Full Text PDFProtective effect of luteinizing hormone on frozen-thawed ovarian follicles and granulosa cells.
PLoS One
January 2025
School of Life Science, Inner Mongolia University, Hohhot, PR China.
Ovarian tissue cryopreservation addresses critical challenges in fertility preservation for prepubertal female cancer patients, such as the lack of viable eggs and hormonal deficiencies. However, mitigating follicle and granulosa cell damage during freeze-thaw cycles remains an urgent issue. Luteinizing hormone (LH), upon binding to luteinizing hormone receptors (LHR) on granulosa cells, enhances estrogen synthesis and secretion, contributing to the growth of granulosa cells and follicles.
View Article and Find Full Text PDFGenistein-3'-sodium sulfonate suppresses NLRP3-mediated cell pyroptosis after cerebral ischemia.
Metab Brain Dis
January 2025
Key Laboratory of Prevention and treatment of cardiovascular and cerebrovascular diseases of Ministry of Education, Gannan Medical University, Ganzhou, 341000, China.
Cerebral ischemia-induced pyroptosis contributes to the dissemination of neuroinflammation, and Nod-like receptor protein-3 (NLRP3) inflammasome plays a key role in this process. Previous studies have indicated that Genistein-3'-sodiumsulfonate (GSS) can inhibit neuroinflammation caused by cerebral ischemia, exert cerebroprotective effects, but its specific mechanism has not been comprehensively understood. The aim of this study was to explore the effect of GSS on ischemic stroke-induced cell pyroptosis.
View Article and Find Full Text PDFNarciclasine attenuates sepsis-associated acute kidney injury through the ESR1/S100A11 axis.
Funct Integr Genomics
January 2025
Department of Emergency and Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210028, People's Republic of China.
Narciclasine (Ncs) was effective in sepsis management due to its antioxidant properties. The present study dissected the protective effects of Ncs against sepsis-associated acute kidney injury (SA-AKI) and the molecular mechanisms. The SA-AKI mice were developed using cecum ligation and puncture and pretreated with Ncs and adenoviruses.
View Article and Find Full Text PDFProtective roles of herbal teas against the toxicity of Bisphenol A on morphometry of uterus and improving murine reproductive health (incomplete title and amended by the EIC).
Pak J Pharm Sci
January 2025
Department of Food Science and Nutrition, Alkhurmah University College, Taif University, Taif, Saudi Arabia.
The purpose of the current study was to investigate the potential ameliorating murine reproductive effects of herbal tea extracts against bisphenol A-induced (BPA) cytotoxicity. A comparative study was applied among red, green and blue teas in mice groups. Samples were coded as RTE, GTE and BTE groups, respectively.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!