AI Article Synopsis
- Antibacterial drugs from the nitrofuran series, like nitrofurazone and nitrofurantoin, and nitric oxide generators such as sodium nitroprusside, were found to boost biofilm formation in certain bacteria.
- At concentrations of 25-100 micrograms/ml, nitrofurans increased biofilm development of Pseudomonas aeruginosa PAO1 by 2-2.5 times, while NO donors raised it by 3-6 times.
- For Burkholderia cenocepacia 370, nitrofurans enhanced biofilm formation by 2-5 times, and sodium nitroprusside increased it by 4.5 times.
Article Abstract
Antibacterial drugs in the nitrofuran series, such as nitrofurazone, furazidin, nitrofurantoin and nifuroxazide, as well as the nitric oxide generators sodium nitroprusside and isosorbide mononitrate in concentrations that do not suppress bacterial growth, were shown to increase the capacity of pathogenic bacteria Pseudomonas aeruginosa PAO1 and Burkholderia cenocepacia 370 to form biofilms. At 25-100microg/ml, nitrofurans 2-2.5-fold enhanced biofilm formation of P. aeruginosa PAO1, and NO donors 3-6-fold. For B. cenocepacia 370, the enhancement was 2-5-fold (nitrofurans) and 4.5-fold (sodium nitroprusside), respectively.
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| http://dx.doi.org/10.1016/j.resmic.2009.04.007 | DOI Listing |
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