The increasing use of brachytherapy in patients with cancer mandates that the informational needs of these patients are met. A nonrandomized sample of 22 patients undergoing brachytherapy participated in a study to determine (1) informational needs, (2) the degree to which patients prefer to be informed about and to participate in their medical care, and (3) the relationship between informational needs and selected variables. Most patients (86.4%) desired maximum information about their illness. The informational needs most frequently identified preimplant were how to manage side effects (54.5%), activity restrictions during implant (54.5%), pain management and comfort measures (54.5%), cause of current symptoms (54.5%), and how the implant could affect symptoms (54.5%). Postimplant needs included when to call the doctor (68%), possible side effects of treatment (64%), and how to manage side effects (63.6%). A significantly lower level of anxiety was found after the implant, compared to before the implant (p less than 0.005). A significant relationship was found between the number of informational needs and the stage of disease. Patients with advanced late disease (stages III and IV) had fewer informational needs than those with early disease (stages I and II), both before and after the implant (p less than 0.05). The results indicate that patients receiving brachytherapy have a variety of informational needs and generally prefer to be fully informed about their condition. The findings indicate possible content areas for educational programs and for counseling of patients undergoing brachytherapy.
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Xenobiotica
January 2025
Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Idiopathic Pulmonary Fibrosis (IPF) is a chronic respiratory disorder for which pirfenidone is the recommended first-line anti-fibrotic treatment. While pirfenidone has demonstrated efficacy in slowing the progression of IPF, its use is associated with several challenges and unresolved issues that impact patient outcomes. Pirfenidone administration can result in gastrointestinal side effects, photosensitivity reactions, and significant drug interactions, particularly in patients with hepatic impairment.
View Article and Find Full Text PDFOtolaryngol Head Neck Surg
January 2025
Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Objective: To provide an updated evaluation of clinical effectiveness and sequelae of maxillomandibular advancement surgery in obstructive sleep apnea.
Data Sources: PubMed, Scopus, CINAHL.
Review Methods: Included studies described patients with obstructive sleep apnea that completed maxillomandibular advancement with any reported sequelae.
Public Health Nutr
January 2025
Faculty of Economics and Management, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
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Postgrad Med J
January 2025
Proof of Concept Center, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital, Second Military Medical University, Naval Medical University, No. 255, Yangpu District, Shanghai, 200433, China.
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Setting: University and hospital with teaching programs in evidence-based medicine.
Therapies against hematological malignancies using chimeric antigen receptors (CAR)-T cells have shown great potential; however, therapeutic success in solid tumors has been constrained due to limited tumor trafficking and infiltration, as well as the scarcity of cancer-specific solid tumor antigens. Therefore, the enrichment of tumor-antigen specific CAR-T cells in the desired region is critical for improving therapy efficacy and reducing systemic on-target/off-tumor side effects. Here, we functionalized human CAR-T cells with superparamagnetic iron oxide nanoparticles (SPIONs), making them magnetically controllable for site-directed targeting.
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