Vital functions and stress hormone levels during simulated emergency helicopter transport in healthy volunteers. Twenty-three volunteers were subjected to a simulated 15 minute rescue helicopter transport. We determined vital functions, ACTH, cortisol and prolactin during the flight and filled in a standardized questionnaire before and after the flight. Data were analysed descriptively, by means of cross tabulation, Spearman rank correlation and cross-correlation technique. During take-off we recorded a significant increase of vital parameters such as heart rate. Prolactin concentration rose slightly after the start. Maximum cortisol and ACTH levels were found before take-off and then they decreased gradually. As expected, ACTH and cortisol cross-correlated significantly without any relevant time lag. Test items showed a feeling of fear and concern before take off. After the flight the volunteers reported having less stress than expected. Particularly, diastolic blood pressure and prolactin levels were markedly associated with questionnaire items such as behaviour of the staff or nausea. Heart rate significantly correlated with anxiety scores. Helicopter transportation induced a marked stress reaction in healthy volunteers, which speaks in favour of smooth transports in modern helicopters and adequate behaviour towards the patient of the staff.
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http://dx.doi.org/10.1556/APhysiol.96.2009.2.7 | DOI Listing |
ACS Nano
January 2025
Medical Research Center, The First Affiliated Hospital of Zhengzhou University, The Center of Infection and Immunity, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Tumor-specific T cells play a vital role in potent antitumor immunity. However, their efficacy is severely affected by the spatiotemporal orchestration of antigen-presentation as well as the innate immune response in dendritic cells (DCs). Herein, we develop a minimalist nanovaccine that exploits a dual immunofunctional polymeric nanoplatform (DIPNP) to encapsulate ovalbumin (OVA) via electrostatic interaction when the nanocarrier serves as both STING agonist and immune adjuvant in DCs.
View Article and Find Full Text PDFHeliyon
July 2024
College of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, China.
Tibetan sheep play a vital role in the livelihoods of herders and are an important part of the ecosystem of the Tibetan Plateau. In order to study the characteristics of the gut microorganisms of Tibetan sheep at high altitude, this study employed macrogenomic techniques to analyse the diversity and differences in the gut flora of Tibetan sheep in different regions of high altitude and high cold. The results demonstrated that at the phylum level, the dominant phylum in the ileo-cecum segment of Tibetan sheep in Qilian, Henan and Gonghe counties was identical, namely , and .
View Article and Find Full Text PDFNarra J
December 2024
Department of Epidemiology, Biostatistics, Population Studies and Health Promotion, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia.
Patients with generalized myasthenia gravis (MG) often show restrictive spirometry results. Although regular exercise and physical fitness are linked to better respiratory function, there is limited research assessing the effects of aerobic exercise on lung function in MG patients. The aim of this study was to analyze the effect of low-intensity aerobic exercise using a cycle ergometer on lung function parameters in MG patients.
View Article and Find Full Text PDFJ Gastrointest Oncol
December 2024
Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Background: Hepatocellular carcinoma (HCC) is a significant health problem associated with several risk factors, increasingly driven by non-alcoholic steatohepatitis and metabolic syndrome. This association poses a challenge for the primary treatments of HCC, which may include immune checkpoint inhibitors and vascular endothelial growth factor inhibitors, due to their potential cardiotoxic effect. Therefore, it is imperative to balance the therapeutic effects of these agents with their potential cardiovascular adverse events.
View Article and Find Full Text PDFAnn Ital Chir
January 2025
Department of Thoracic Surgery, Mindong Hospital Affiliated to Fujian Medical University, 355000 Fu'an, Fujian China.
Aim: This study aimed to explore the efficacy of open reduction and internal fixation assisted by handheld ultrasound combined with three-dimensional (3D) printing technology in treating multiple rib fractures.
Methods: We retrospectively analyzed the clinical data from 84 patients affected with multiple rib fractures admitted to our hospital between August 2022 and April 2024. After excluding four cases, 80 cases were included in this study.
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