A 58-year-old man presented in 2001 with dysplastic nevus syndrome with at least 300 nevi and about 100 clinically highly atypical nevi. Three melanomas had been excised by a private dermatologist within the past year. We then removed two additional melanomas. Between 2002 and 2003, 117 nevi which were atypical on dermatoscopy were removed; most by horizontal (shave) excision. Adequate clinical and dermatoscopic control was not feasible due to the large number of atypical nevi. In order to reduce the number of nevus cells, we treated test sites with both dermabrasion and split-thickness excision. The latter proved to be more efficient and was used to completely excise the skin of the back, as well as parts of the arms and chest in two sessions under general anesthesia. Wound healing was uneventful. Following these procedures, adequate clinical and dermatoscopic monitoring of the remaining nevi was possible and only a few had to be removed. No more melanomas appeared in the treated areas.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1610-0387.2009.07095.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Benign Nevi Mimicking Melanoma: A Diagnostic Dilemma.
Cureus
November 2024
Medicine, Batterjee Medical College, Jeddah, SAU.
Article Synopsis
- * Misdiagnosis (both under and over) of melanomas occurs frequently because benign lesions can mimic melanoma characteristics.
- * Accurate diagnosis relies on strong clinico-pathological correlation, detailed cytological analysis, and appropriate use of immunohistochemistry to prevent harmful misdiagnoses.
Grading Melanocytic Dysplasia: Updated Histopathologic Criteria.
J Cutan Pathol
November 2024
Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Article Synopsis
- Dr. Martin C. Mihm, Jr. contributed significantly to the World Health Organisation Classification of Skin Tumours with his work on dysplastic nevi, emphasizing a dual classification system based on grade.
- His proposed method includes a quantitative assessment of melanocytic nuclear enlargement, enhancing the evaluation of these skin lesions.
- The paper also aims to refine existing grading systems by integrating WHO-C definitions and improving the Duke classification's quantitative and architectural criteria for better assessment of dysplastic nevi.
SOX-10 and Melan-A Immunostaining in Areas of Focal Acantholytic Dyskeratosis and Epidermolytic Hyperkeratosis Within Dysplastic Nevi Biopsies: An Observational Study.
Am J Dermatopathol
January 2025
Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, OH; and.
Background: Focal acantholytic dyskeratosis (FAD) and epidermolytic hyperkeratosis (EHK) are common incidental epidermal histologic findings within dysplastic nevi biopsies. We evaluate whether areas of FAD and EHK within dysplastic nevi biopsies stain with immunostains used to characterize melanocytic neoplasms.
Methods: In this case series, a natural language search of histopathology reports from our institution in the past year (2020-2021) identified dysplastic nevus biopsies with concurrent FAD and/or EHK.
Deep Learning With Optical Coherence Tomography for Melanoma Identification and Risk Prediction.
J Biophotonics
October 2024
Institute of Biophotonics, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Article Synopsis
- Malignant melanoma is a serious skin cancer that is becoming more common, prompting the need for effective early detection methods.
- Previous studies mostly focused on dermoscopic images, but this research uses a convolutional neural network (CNN) to analyze optical coherence tomography (OCT) images of mouse skin for better melanoma identification.
- The CNN shows impressive accuracy with a sensitivity of 0.99 and specificity of 0.98, providing a risk score for melanoma presence that could help improve early diagnosis and treatment in clinical practices.
Utilizing PRAME Expression and a Meta-Analytic Framework for iSALT to Explore Atypical Late-Onset Nevi of the Elderly and Their Relationship With Lentiginous and Nested Nevoid Melanomas.
Am J Dermatopathol
December 2024
Kossard Dermatopathologists, Laverty Pathology, Macquarie Park, NSW, Australia .
Background: In contrast to early-onset dysplastic nevi, late-onset atypical nevi of the elderly are more often precursors to distinctive nevoid melanomas. PReferentially expressed Antigen in MElanoma (PRAME) immunohistochemistry was applied to delineate the nevoid aspect of late-onset oncogenic nevoid pathway. Inducible Skin-Associated Lymphoid Tissue, regulatory T-cell mesenchymal hubs, has emerged as a translational tool and was used to define nevoid oncogenesis within a dynamic meta-analytic pathway.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!