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Dermoscopy of Lichen Planus Pigmentosus and Histopathological Correlation: A Case Series.
Dermatol Pract Concept
October 2024
Dermatology Department, Habib Thameur Hospital, Tunis, Tunisia.
Introduction: Lichen planus pigmentosus (LPP) is an acquired pigmentary disorder affecting the dark-skinned population. There is a wide range of differentials, with substantial clinicopathological overlap. Dermoscopy may contribute to the better characterization of this dermatosis.
View Article and Find Full Text PDFFollicular Dowling-Degos Disease Camouflaged as Comedones: A Case Report and Literature Review.
Cureus
June 2022
Dermatology, All India Institute of Medical Sciences, Mangalagiri, Guntur, IND.
Dowling-Degos disease (DDD) is an uncommon autosomal dominant genodermatosis that resides in the spectrum of diseases presenting with reticulate pigmentation. This disease has varied phenotypic expressions, the classical presentation being reticular pigmentation of flexures involving the axilla, submammary folds, inguinal folds, and neck. Follicular DDD is a variant of DDD with a unique presentation of folliculocentric papules, macules, pits, and comedones associated with the characteristic histological findings of follicle-centered, pigmented, branching, antler horn-like rete ridges sparing the interfollicular epidermis.
View Article and Find Full Text PDFEffects of NCSTN Mutation on Hair Follicle Components in Mice.
Dermatology
January 2023
People's Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Background And Objectives: Hidradenitis suppurativa (HS)/acne inversa is an intractable skin disease that is characterized by destructive lesions - primarily on the flexural areas. Although its etiology is unknown, genetics is considered to be a factor of its pathology - mutations in γ-secretase genes have been identified in certain familial HS patients, and follicular occlusion is widely accepted as the primary cause of HS. But, no relationship between these mutations and the components of hair follicles has been reported.
View Article and Find Full Text PDFA Case of Generalized Lichen Sclerosus et Atrophicus.
Ann Dermatol
August 2020
Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea.
A 62-year-old female, with previous history of asthma and hypertension, presented with generalized hyperpigmented skin lesion, found a year ago. Physical examination revealed brown colored lichenified and sclerotic patches on the lower abdomen and flexural areas of extremities. Punch biopsy was performed and histopathological examination revealed hyperkeratosis, follicular plugging and thinning in epidermis.
View Article and Find Full Text PDFPhenotypic expansion of POFUT1 loss of function mutations in a disorder featuring segmental dyspigmentation with eczematous and folliculo-centric lesions.
Am J Med Genet A
December 2019
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
Appearance of mosaic disorders in thin Blaschko lines suggests that somatic mutations in keratinocyte precursors underlie their pathogenesis. Germline heterozygous mutations in POFUT1 gene cause Dowling-Degos disease (DDD), a skin disease that features flexural reticulated hyperpigmentation and follicular-based lesions. POFUT1 mosaicism has not been described to date.
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