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Adult Human Heart ECM Improves Human iPSC-CM Function via Mitochondrial and Metabolic Maturation.
Stem Cells
January 2025
Bioengineering Graduate Program, University of Notre Dame, Notre Dame, 46556 IN, USA.
Myocardial infarction can lead to the loss of billions of cardiomyocytes, and while cell-based therapies are an option, immature nature of in vitro-generated human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iCMs) is a roadblock to their development. Existing iPSC differentiation protocols don't go beyond producing fetal iCMs. Recently, adult extracellular matrix (ECM) was shown to retain tissue memory and have some success driving tissue-specific differentiation in unspecified cells in various organ systems.
View Article and Find Full Text PDFRole of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis.
Biology (Basel)
January 2025
Department of Hematology, the Second Xiangya Hospital, School of Life Sciences, Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha 410011, China.
B-cell lymphoma/leukemia 11A (BCL11A) is a crucial transcriptional regulator, widely recognized for its role in controlling fetal hemoglobin and its potential as a gene therapy target for inherited hemoglobinopathies. Beyond this, recent studies have also highlighted its key role in the maturation and function of immune cells and erythrocytes, mediated through the regulation of various molecules during hematopoietic development. The dysregulation of BCL11A disrupts downstream molecular pathways, contributing to the development of several hematological malignancies, particularly leukemias.
View Article and Find Full Text PDFAn extra X chromosome: dissecting its role in male fetal germ cell maturation.
Sci China Life Sci
January 2025
School of Life Sciences, Fudan University, Shanghai, 200433, China.
Prenatal depression and child developmental vulnerability.
Pediatr Res
January 2025
Department of Gynaecology and Obstetrics, University of British Columbia (UBC), Vancouver, BC, 590-828 W 10th Ave, Vancouver, BC, V5Z 1M9, Canada.
Background: Prenatal depression is a potentially important fetal exposure as it may alter fetal development and have lasting effects.
Methods: We examined all live births from 2001 to 2012 in British Columbia with follow-up data on the Early Development Instrument (EDI) in Kindergarten. The odds of developmental vulnerability on EDI domains among those with and without depression during pregnancy were estimated.
Supplementation with N-Acetyl-L-cysteine during in vitro maturation improves goat oocyte developmental competence by regulating oxidative stress.
Theriogenology
January 2025
Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, 550025, China; Key Laboratory of Animal Genetics, Breeding and Reproduction of Guizhou Province, Guiyang, 550025, China; College of Animal Science, Guizhou University, Guiyang, 550025, China. Electronic address:
Oocyte quality can affect mammal fertilization rate, early embryonic development, pregnancy maintenance, and fetal development. Oxidative stress induced by reactive oxygen species (ROS) is one of the most important causes of poor oocyte maturation in vitro. To reduce the degree of cellular damage caused by ROS, supplementation with the antioxidant N-Acetyl-L-cysteine (NAC) serves as an effective pathway to alleviate glutathione (GSH) depletion during oxidative stress.
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