Emdogain has been available commercially for just over a decade. It is used currently in clinical practice of periodontics and has been investigated in four clinical outcome studies of replanted teeth. This review covers the origin and concepts behind the use of this amelogenin derivative, the unique conditions associated with an avulsed tooth, and the laboratory and clinical characteristics of this material. Emdogain continues to be an experimental material for replantation applications.
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Recombinant human amelogenin promotes wound healing by enhancing angiogenesis.
Biochem Biophys Res Commun
November 2024
Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address:
The first barrier of the human body is the skin, and more serious harm may occur when skin wound healing is delayed. One of the components of enamel matrix proteins is amelogenin, which inhibits inflammation and promotes periodontal tissue regeneration. However, its role in skin wound healing and angiogenesis is inconclusive.
View Article and Find Full Text PDFAffinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis.
Sci Rep
July 2023
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Proteos, Singapore, 138673, Singapore.
It is challenging to regenerate periodontal tissues fully. We have previously reported a heparan sulfate variant with enhanced affinity for bone morphogenetic protein-2, termed HS3, that enhanced periodontal tissue regeneration in a rodent model. Here we seek to transition this work closer to the clinic and investigate the efficacy of the combination HS3 collagen device in a non-human primate (NHP) periodontitis model.
View Article and Find Full Text PDFEffects of Enamel Matrix Derivative on Cell Spheroids Made of Stem Cells Obtained from the Gingiva on Osteogenic Differentiation.
Medicina (Kaunas)
February 2023
Department of Periodontics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
: A derivative of the enamel matrix was used to speed up periodontal regeneration, including the formation of new cementum, alveolar bone, and periodontal ligament. In this study, human gingiva-derived stem cell-derived cell spheroids were used to assess the effects of an enamel matrix derivative on cell viability, osteogenic differentiation, and mineralization. : Human gingiva-derived stem cells were used to create spheroids, which were then coupled with unloaded control groups and an enamel matrix derivative at a final concentration of 2.
View Article and Find Full Text PDFData from ameloblast cell lines cultured in 3D using various gel substrates in the presence of ameloblastin.
Data Brief
June 2022
Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, United States.
This article contains data related to the research article in this issue titled ameloblastin promotes polarization of ameloblast cell lines in a 3D cell culture system (Visakan et al., 2022). In the process of amelogenesis, the organic matrix components are pivotal to the establishment of ameloblast-matrix adhesion.
View Article and Find Full Text PDFRegenerative Periodontal Therapy in Intrabony Defects and Long-Term Tooth Prognosis.
Dent Clin North Am
January 2022
Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.
In this chapter, the results from a relatively recently performed systematic appraisal of the literature on the long-term outcome of regenerative periodontal treatment in intrabony defects are presented. Periodontal regenerative procedures in intrabony defects yield significantly better clinical outcomes compared with conventional surgery and result in high rates of tooth retention on a medium- to long-term basis. Combination approaches seem, in general, more efficacious compared with monotherapy.
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