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Alzheimers Dement
December 2024
Massachusetts Alzheimer's Disease Research Center, Charlestown, MA, USA.
Background: In cerebral amyloid angiopathy, amyloid beta accumulates within the walls of blood vessels and contributes to impaired vascular integrity and function. In this work, we observe that tau protein similarly builds up along blood vessels in Alzheimer's disease brain.
Method: We obtained frozen inferior temporal cortex from the Massachusetts Alzheimer's Disease Research Center from n = 7 neuropathological confirmed Alzheimer's disease donors and n = 6 normal aging controls.
Analysis of spatial patellofemoral alignment using novel three-dimensional measurements based on weight-bearing cone-beam CT.
Insights Imaging
January 2025
Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Objectives: To propose a reliable and standard 3D assessment method to analyze the effect of weight-bearing (WB) status on the location of patella and clarify the diagnostic performance of 3D parameters for recurrent patellar dislocation (RPD) in WB and non-weight-bearing (NWB) conditions.
Methods: Sixty-five knees of RPD patients and 99 knees of controls were included. Eight landmarks, two lines and a coordinate system were defined on 3D bone models of knees based on weight-bearing CT and non-weight-bearing CT.
Age-related morphological changes of the pubic symphyseal surface: using three-dimensional statistical shape modeling.
Sci Rep
January 2025
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, 03722, Republic of Korea.
Computational analysis of the pubic symphyseal surface is widely used for accurate age estimation, offering quantitative precision through the detection of subtle morphological changes. However, these methods often lack insights into the underlying morphological changes across different age groups. To bridge this gap, the study utilizes statistical shape modeling (SSM), a versatile tool capable of describing diverse morphological variations within populations.
View Article and Find Full Text PDFA microfluidics platform for simultaneous evaluation of sensitivity and side effects of anti-cancer drugs using a three-dimensional culture method.
Sci Rep
January 2025
Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu , Tokyo, 183-8509, Japan.
Organoids are stem cell-derived three-dimensional tissue cultures composed of multiple cell types that recapitulate the morphology and functions of their in vivo counterparts. Organ-on-a-chip devices are tiny chips with interconnected wells and channels designed using a perfusion system and microfluidics to precisely mimic the in vivo physiology and mechanical forces experienced by cells in the body. These techniques have recently been used to reproduce the structure and function of organs in vitro and are expected to be promising alternatives for animal experiments in the future.
View Article and Find Full Text PDFSucrose synthase gene family in common bean during pod filling subjected to moisture restriction.
Front Plant Sci
December 2024
Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCYT)-Facultad de Ciencias Químicas, Universidad Veracruzana, Orizaba, Veracruz, Mexico.
In common bean ( L.), leaf photosynthesis is significantly reduced under drought conditions. Previous studies have shown that some drought-tolerant cultivars use the pod walls to compensate the decreased photosynthesis rate in leaves by acting as temporary reservoirs of carbohydrates to support seed filling.
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