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Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets.
Cell
January 2017
Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA. Electronic address:
Phase transitions driven by intrinsically disordered protein regions (IDRs) have emerged as a ubiquitous mechanism for assembling liquid-like RNA/protein (RNP) bodies and other membrane-less organelles. However, a lack of tools to control intracellular phase transitions limits our ability to understand their role in cell physiology and disease. Here, we introduce an optogenetic platform that uses light to activate IDR-mediated phase transitions in living cells.
View Article and Find Full Text PDFPatient-to-patient variability in autologous pericardial matrix scaffolds for cardiac repair.
J Cardiovasc Transl Res
October 2011
University of California, San Diego, La Jolla, CA, USA.
The pursuit of alternate therapies for end-stage heart failure post-myocardial infarction has led to the development of a variety of in situ gelling materials to be used as cellular or acellular scaffolds for cardiac repair. Previously, a protocol was established to decellularize human and porcine pericardia and process the extracellular matrix (ECM) into an injectable form. The resulting gels were found to retain components of the native extracellular matrix; cell infiltration was facilitated in vivo, and neovascularization was observed by 2 weeks.
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