AI Article Synopsis
- Researchers successfully modified poly(ethylene glycol) (PEG) by adding disulfide bonds, giving it temperature sensitivity and making it biodegradable.
- By adjusting the ratio of PEG with different molecular masses (400 Da and 600 Da), they were able to lower the cloud point of the polymer solution from 35°C to 27°C, targeting a physiologically relevant temperature range (20-40°C).
- The disulfide bonds in the PEG degraded when exposed to glutathione, a biomolecule containing thiol, demonstrating a concentration-dependent response to thiol levels.
Article Abstract
We report here that the incorporation of several disulfide bonds along poly(ethylene glycol) (PEG) gives temperature sensitivity, as well as biodegradability to PEG. To synthesize a PEG with temperature sensitivity in a physiologically important range (20-40 degrees C), PEGs with molecular masses of 400 and 600 Da were randomly coupled by disulfide bonds. As the mol ratio of PEG (400 Da) disulfide to PEG (600 Da) disulfide increased from 40:60 to 60:40, the cloud point of the polymer aqueous solution decreased from 35 degrees C to 27 degrees C. The disulfide bonds between PEGs were degraded in the presence of a thiol-containing biomolecule of glutathione in a thiol-concentration-dependent manner.
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| http://dx.doi.org/10.1163/156856209X444367 | DOI Listing |
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