Introduction: Amoebic dysentery is caused by the protozoan parasite Entamoeba histolytica. It is transmitted in areas where poor sanitation allows contamination of drinking water and food with faeces. In these areas, up to 40% of people with diarrhoea may have amoebic dysentery.
Methods And Outcomes: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of drug treatments for amoebic dysentery in endemic areas? We searched: Medline, Embase, The Cochrane Library and other important databases up to July 2006 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
Results: We found 11 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following interventions: emetine, metronidazole, ornidazole, paromomycin, secnidazole, and tinidazole.
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Article Synopsis
- Entamoeba histolytica is a parasite causing intestinal amebiasis, particularly prevalent in tropical areas and a major health issue in developing countries. Traditional diagnostic methods can cause delays in treatment, exacerbating patient conditions.
- A case involving a 59-year-old HIV-positive man revealed how initial testing misdiagnosed his illness, but advanced diagnostics using the FilmArray GI Panel quickly identified E. histolytica in under an hour.
- The successful and prompt treatment with antiamoebic drugs significantly improved the patient's health, highlighting the importance of rapid diagnosis in managing gastrointestinal infections effectively.
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