Background: Agricultural science can address a population's vitamin, amino acid and mineral malnutrition through biofortification - agronomy, plant breeding and biotechnology to develop crops with high nutrient contents. Biofortified crop varieties should be grown in areas with populations at risk of nutrient deficiency and in areas where the same crop is already grown and consumed. Information on the population at risk of nutrient deficiency is rarely available for sub-national administrative units, such as provinces, districts, and municipalities. Nor is this type of information commonly analyzed with data on agricultural production. This project developed a method to identify populations at risk of nutrient deficiency in zones with high crop production, places where biofortification interventions could be targeted.
Results: Nutrient deficiency risk data were combined with crop production and socioeconomic data to assess the suitability of establishing an intervention. Our analysis developed maps of candidate sites for biofortification interventions for nine countries in Latin America and the Caribbean. Results for Colombia, Nicaragua, and Bolivia are presented in this paper. Interventions in northern Colombia appear promising for all crops, while sites for bean biofortification are widely scattered throughout the country. The most promising sites in Nicaragua are found in the center-north region. Candidate sites for biofortification in Bolivia are found in the central part of the country, in the Andes Mountains. The availability and resolution of data limits the analysis. Some areas show opportunities for biofortification of several crops, taking advantage of their spatial coincidence. Results from this analysis should be confirmed by experts or through field visits.
Conclusion: This study demonstrates a method for identifying candidate sites for biofortification interventions. The method evaluates populations at risk of nutrient deficiencies for sub-national administrative regions, and provides a reasonable alternative to more costly, information-intensive approaches.
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http://dx.doi.org/10.1186/1476-072X-8-29 | DOI Listing |
Phys Chem Chem Phys
January 2025
National Engineering Research Centre for Mg Alloys, Chongqing University, Chongqing 400044, PR China.
Rechargeable Mg batteries are promising candidates for achieving considerable high-energy-density. Enhancing the energy density can be achieved by integrating metallic Mg anodes with conversion-type cathode materials, which are characterized by multi-electron transfer process and elevated specific capacities in contrast to intercalation-type materials. Despite these advantages, the conversion-type cathodes still have some challenges of substantial volume expansion, sluggish diffusion kinetics and intricate mesophase evolution during repeated electrochemical reactions.
View Article and Find Full Text PDFCurr Comput Aided Drug Des
January 2025
Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, Deoghat, Jhalwa, Prayagraj Uttar Pradesh, 211015, India.
Introduction: Multidrug-resistant (MDR) E. coli presents a significant challenge in clinical settings, necessitating the exploration of novel therapeutic agents. Phytochemicals from Punica granatum (pomegranate) leaves have shown potential antibacterial properties.
View Article and Find Full Text PDFJ Allergy Clin Immunol
January 2025
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN; Department of Pharmacology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN. Electronic address:
Background: Human monoclonal IgE antibodies recognizing peanut allergens have recently become available, but we lack a detailed understanding of how these IgEs target allergens.
Objective: To determine the molecular details of the antibody-allergen interaction for a panel of clinically important human IgE monoclonal antibodies and to develop strategies to disrupt disease causing antibody-allergen interactions.
Methods: We identified candidates from a panel of epitope binned human IgE monoclonals that recognize two important and homologous peanut allergens, Ara h 2 and Ara h 6.
Nanoscale
January 2025
Centre for Nano and Soft Matter Sciences (CeNS), Shivanapura, Bengaluru 562162, India.
Bifunctional oxygen electrocatalysis is a pivotal process that underpins a diverse array of sustainable energy technologies, including electrolyzers and fuel cells. Metal selenides have been identified as highly promising candidates for oxygen electrocatalysts with electronic structure engineering that lies at the heart of catalyst design. Two-phase Fe-doped nitrogen carbon (NC)-supported nickel selenides were synthesized using a coordination polymer template.
View Article and Find Full Text PDFDefects in DNA single-strand break repair are associated with neurodevelopmental and neurodegenerative disorders. One such disorder is that resulting from mutations in , a scaffold protein that plays a central role in DNA single-strand base repair. XRCC1 is recruited at sites of single-strand breaks by PARP1, a protein that detects and is activated by such breaks and is negatively regulated by XRCC1 to prevent excessive PARP binding and activity.
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