Micronutrient deficiencies (MNDs) contribute significantly to the world's disease and mortality burden. Global efforts addressing MNDs have achieved significant yet heterogeneous progress across and within regions and countries. For vitamin A and iodine interventions, enhancing achievements in coverage require further political and financial commitment and targeting of hard-to-reach populations. Anemia control must focus on prevention among preschoolers and adolescent women and on integrated public health programs. Current international guidelines on iron supplementation and cut-off values for anemia need revision. For zinc, advocacy to accelerate the application of revised diarrhea management guidelines is critical, as are efficacy studies on food-based interventions and preventive supplementation.
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http://dx.doi.org/10.1111/j.1753-4887.2009.00155.x | DOI Listing |
Blood
December 2024
Versiti Blood Research Institute, Milwaukee, Wisconsin, United States.
Starting with imatinib, tyrosine kinase inhibitors (TKIs) have turned chronic myeloid leukemia (CML) from a lethal blood cancer into a chronic condition. As patients with access to advanced CML care have an almost normal life expectancy, there is a perception that CML is a problem of the past, and one should direct research resources elsewhere. However, a closer look at the current CML landscape reveals a more nuanced picture.
View Article and Find Full Text PDFIn unsupervised transfer learning for medical image segmentation, where existing algorithms face the challenge of error propagation due to inaccessible source domain data. In response to this scenario, source-free domain transfer algorithm with reduced style sensitivity (SFDT-RSS) is designed. SFDT-RSS initially pre-trains the source domain model by using the generalization strategy and subsequently adapts the pre-trained model to target domain without accessing source data.
View Article and Find Full Text PDFPLoS One
December 2024
Xiangya School of Nursing, Central South University, Changsha, Hunan, PR China.
Background: Improving the efficiency of ophthalmology service is a global challenge to fight vision impairment, yet there is little concrete evidence of the current efficiency status. This study aimed to examine the efficiency of ophthalmology departments in the Hunan Province, China, and determine the associating factors of low-efficiency and high-efficiency ophthalmology departments.
Methods: This cross-sectional study included a province-level survey of ophthalmology departments of public hospitals.
J Xray Sci Technol
December 2024
School of Electrical and Information Engineering, Tianjin University, Nankai District, Tianjin, China.
Background: Airport security is still a main concern for assuring passenger safety and stopping illegal activity. Dual-energy X-ray Imaging (DEXI) is one of the most important technologies for detecting hidden items in passenger luggage. However, noise in DEXI images, arising from various sources such as electronic interference and fluctuations in X-ray intensity, can compromise the effectiveness of object identification.
View Article and Find Full Text PDFBioconjug Chem
December 2024
School of Medicine and Health, Harbin Institute of Technology, Harbin 150080, China.
Self-propelled micro/nanomotors (MNMs) represent a groundbreaking advancement in precision drug delivery, offering potential solutions to persistent challenges such as systemic toxicity, limited bioavailability, and nonspecific distribution. By transforming various energy sources into mechanical motion, MNMs are able to autonomously navigate through complex physiological environments, facilitating targeted delivery of therapeutic agents to previously inaccessible regions. However, to achieve efficient in vivo drug delivery, biomedical MNMs must demonstrate their ability to overcome crucial physiological barriers encompassing mucosal surfaces, blood flow dynamics, vascular endothelium, and cellular membrane.
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