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Over a Century of Study and Still Misunderstood: Recognizing the Spectrum of Acute and Chronic Wernicke-Korsakoff Syndrome.
J Clin Med
October 2023
Melbourne School of Psychological Sciences, Redmond Barry Building, University of Melbourne, Parkville, VIC 3010, Australia.
Article Synopsis
- - The study aimed to evaluate the typical neuropsychological profile of Korsakoff's syndrome, traditionally characterized by severe amnesia paired with relatively intact intellectual abilities, by examining the cases of nine adult male patients with a history of Wernicke-Korsakoff syndrome.
- - Contrary to common belief, the findings indicated that cognitive impairment in these patients was more variable than previously thought, with some exhibiting general intellectual decline alongside memory issues, rather than preserved intellect.
- - The results suggest that clinicians should reconsider the established understanding of Korsakoff's syndrome and broaden diagnostic criteria to accommodate diverse cognitive profiles, which may allow for better treatment approaches.
Dietary Methionine via Dose-Dependent Inhibition of Short-Chain Fatty Acid Production Capacity Contributed to a Potential Risk of Cognitive Dysfunction in Mice.
J Agric Food Chem
December 2022
National Engineering Laboratory/Key Laboratory of Henan Province, College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, China.
High-methionine diets induce impaired learning and memory function, dementia-like neurodegeneration, and Alzheimer's disease, while low-methionine diets improve learning and memory function. We speculated that variations in intestinal microbiota may mediate these diametrically opposed effects; thus, this study aimed to verify this hypothesis. The ICR mice were fed either a low-methionine diet (LM, 0.
View Article and Find Full Text PDFAmeliorative effect of vanillin on scopolamine-induced dementia-like cognitive impairment in a mouse model.
Front Neurosci
November 2022
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Background: Alzheimer's disease (AD) is the most common form of dementia, which is among the top five causes of death in the United States. It is a neurodegenerative disorder that causes permanent loss of memory and cognition. The current pharmacotherapy for AD is based on providing symptomatic relief only and has many side effects.
View Article and Find Full Text PDFAccuracy of MRI derived cerebral aqueduct flow parameters in the diagnosis of idiopathic normal pressure hydrocephalus.
J Clin Neurosci
November 2022
Department of Radiology, Taichung Veterans General Hospital, 1650 Sect. 4 Taiwan, Boulevard, Taichung 40705, Taiwan, ROC.
Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible cause of dementia-like symptoms among the elderly. Current diagnostic guidelines for iNPH rely on clinical manifestations and ventricular morphology, which often lack accuracy. While magnetic resonance imaging (MRI) CSF flowmetry of the cerebral aqueduct provides a noninvasive aid to differential diagnosis, previous studies suffered from small sample sizes.
View Article and Find Full Text PDFAutologous skin-derived neural precursor cell therapy reverses canine Alzheimer dementia-like syndrome in a proof of concept veterinary trial.
Stem Cell Res Ther
June 2022
University of New England, Armidale, Australia.
Background: Older companion dogs naturally develop a dementia-like syndrome with biological, clinical and therapeutic similarities to Alzheimer disease (AD). Given there has been no new safe, clinically effective and widely accessible treatment for AD for almost 20 years, an all-new cell therapeutic approach was trialled in canine veterinary patients, and further modelled in aged rats for more detailed neurobiological analysis.
Methods: A Phase 1/2A veterinary trial was conducted in N = 6 older companion dogs with definitive diagnosis of Canine Cognitive Dysfunction (CCD).
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