AI Article Synopsis
- Traditional heart failure treatments focus on neurohormonal systems and heart structure changes, but heart failure still poses significant health risks.
- There is growing interest in managing heart health by influencing how the heart uses glucose, particularly through glucose-insulin-potassium (GIK) infusions, which have shown mixed results in heart attack treatment.
- New research highlights glucagon-like peptide-1 (GLP-1) as a promising option for improving heart function in patients with left ventricular systolic dysfunction, backed by studies in both animals and humans.
Article Abstract
Pharmacologic intervention for the failing heart has traditionally targeted neurohormonal activation and ventricular remodeling associated with cardiac dysfunction. Despite the multitude of agents available for the treatment of heart failure, it remains a highly prevalent clinical syndrome with substantial morbidity and mortality, necessitating alternative strategies of targeted management. One such area of interest is the ability to modulate myocardial glucose uptake and its impact on cardioprotection. Glucose-insulin-potassium (GIK) infusions have been studied for decades, with conflicting results regarding benefit in acute myocardial infarction. Based on the same concepts, glucagon-like peptide-1-[7-36] amide (GLP-1) has recently been demonstrated to be a more effective alternative in left ventricular (LV) systolic dysfunction. This paper provides a review on the current evidence supporting the use of GLP-1 in both animal models and humans with ischemic and nonischemic cardiomyopathy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653299 | PMC |
| http://dx.doi.org/10.1002/clc.20456 | DOI Listing |
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