Objective: To estimate the lifetime economic consequences of glaucoma in France.
Methods: A Markov model estimated the average discounted outcome and cost of glaucoma treatment over a patient's lifetime. Clinical states were defined as first- to fourth-line drugs, no treatment, laser therapy, surgery, blindness and death. After each failure (always after the fourth-line drug) patients could receive either laser treatment or surgery followed by no treatment, or a new treatment. A societal perspective was adopted. Sensitivity analyses were performed.
Results: Discounted medical costs were euro 7,322 for ocular hypertension treatment (OHT) and euro 8,488 for a glaucoma patient. Social costs of OHT and glaucoma patients exceeded medical costs. First-line use of the most effective drug would reduce medical and social costs. Societal willingness to pay for the vision benefit would equal the medical costs. Treatment initiated with the most effective drug is a cost saving strategy.
Conclusions: Public health decisions in glaucoma treatment should take a broad economic view embracing the lifetime duration of the disease. There is still a place both within and outside the healthcare system for therapeutic innovations with important economic consequences that bring high added value to patients.
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http://dx.doi.org/10.3111/13696990902728729 | DOI Listing |
PeerJ
January 2025
College of Agronomy, Guizhou University, Guiyang, Guizhou, China.
Background: is an important cash crop in southwestern China, with soil organic carbon playing a vital role in soil fertility, and microorganisms contributing significantly to nutrient cycling, thus both of them influencing tea tree growth and development. However, existing studies primarily focus on soil organic carbon, neglecting carbon fractions, and the relationship between soil organic carbon fractions and microbial communities is unclear. Consequently, this study aims to clarify the impact of different tea planting durations on soil organic carbon fractions and microbial communities and identify the main factors influencing microbial communities.
View Article and Find Full Text PDFBMC Health Serv Res
January 2025
Inland School of Business and Social Science, University of Inland Norway, Campus Lillehammer, 2604, Lillehammer, Norway.
Background: The concept of thriving at work (TAW) has received increased interest within health services research in recent years. TAW embraces employees' experience of being energized and feeling alive when employed in an organization. However, previous research has been limited mainly to the investigation of factors that promote TAW.
View Article and Find Full Text PDFBMC Geriatr
January 2025
Department of Health Economics, School of Public Health, Fudan University, 130 Dong'an Road, Shanghai, 200032, China.
Background: Multimorbidity has emerged as a significant challenge for healthcare systems globally. This study aims to examine the associations between key determinants of lifestyle behavior and various multimorbidity patterns.
Methods: In a cross-sectional sample of older adults (aged 60-79) from the Fifth National Physical Fitness Surveillance in Shanghai, latent class analysis (LCA) was used to identify multimorbidity patterns among 9 chronic diseases.
Nat Commun
January 2025
Florida Museum of Natural History, Dickinson Hall, 1659 Museum Road, Gainesville, FL, 32611, USA.
The Thorny Skate (Amblyraja radiata) is a vulnerable species displaying a discrete size-polymorphism in the northwest Atlantic Ocean (NWA). We conducted whole genome sequencing of samples collected across its range. Genetic diversity was similar at all sampled sites, but we discovered a ~ 31 megabase bi-allelic supergene associated with the size polymorphism, with the larger size allele having introgressed in the last ~160,000 years B.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
February 2025
Cognitive Science Program, Indiana University, Bloomington, IN 47405.
Automation transformed various aspects of our human civilization, revolutionizing industries and streamlining processes. In the domain of scientific inquiry, automated approaches emerged as powerful tools, holding promise for accelerating discovery, enhancing reproducibility, and overcoming the traditional impediments to scientific progress. This article evaluates the scope of automation within scientific practice and assesses recent approaches.
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