AI Article Synopsis
- Earlier menarche is linked to shorter adult height and increased childhood body fat, and a study analyzed this in 15,297 Icelandic women.
- A significant genetic variant (rs314280[T]) near the LIN28B gene was found to delay age at menarche by about 1.2 months per allele, with further analysis identifying two haplotypes that influence this timing differently.
- The study suggests that while some genetic factors affect height and age at menarche, they act independently from each other, and additional variants related to higher body mass index were also evaluated for their connection to menarche timing.
Article Abstract
Earlier menarche correlates with shorter adult height and higher childhood body fat. We conducted a genome-wide association study of age at menarche (AAM) on 15,297 Icelandic women. Combined analysis with replication sets from Iceland, Denmark and the Netherlands (N = 10,040) yielded a significant association between rs314280[T] on 6q21, near the LIN28B gene, and AAM (effect = 1.2 months later per allele; P = 1.8 × 10(-14)). A second SNP within the same linkage disequilibrium (LD) block, rs314277, splits rs314280[T] into two haplotypes with different effects (0.9 months and 1.9 months per allele). These variants have been associated with greater adult height. The association with adult height did not account for the association with AAM or vice versa. Other variants, previously associated with height, did not associate significantly with AAM. Given the link between body fat and AAM, we also assessed 11 variants recently associated with higher body mass index (BMI) and 5 of those associated with earlier AAM.
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| http://dx.doi.org/10.1038/ng.383 | DOI Listing |
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