AI Article Synopsis
- A study analyzed HBeAg, anti-HBe, and hepatitis B virus (HBV) DNA in 34 HIV-1-infected children from Ivory Coast with chronic hepatitis B (CHB), assessing the relationship with CD4 levels and HIV-1 RNA.
- Results showed that children with typical CHB had significantly lower CD4% values (15.1%) compared to those with other HBV profiles (18.5% and 20.0%).
- Higher HIV-1 RNA concentrations were found in HBV DNA-positive samples (4.47 and 4.30 log(10)/ml) compared to HBV DNA-negative samples (3.43 log(10)/ml), highlighting the impact of HIV
Article Abstract
HBeAg/anti-HBe and hepatitis B virus (HBV) DNA from 34 HIV-1-infected children from Ivory Coast with chronic hepatitis B (CHB) were longitudinally analyzed according to CD4 and HIV-1 RNA. The mean CD4% value was significantly (p = 0.03) lower in 59 (52.7%) samples showing a usual CHB (HBeAg-positive/anti-HBe-negative and HBV DNA-positive), as compared with 30 (26.8%) HBeAg-positive/anti-HBe-positive and HBV DNA-positive and 23 (20.5%) HBeAg-negative/anti-HBe-positive and HBV DNA-negative (15.1% vs. 18.5% and 20.0%). The mean HIV-1 RNA concentrations were significantly (p = 0.01) higher in specimens HBV DNA-positive (4.47 and 4.30 log(10)/ml, respectively) vs. HBV DNA-negative (3.43 log(10)/ml). HIV-1 has a significant impact on CHB acquired in childhood.
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