Background: Cancer is the leading cause of death in the United States, and the probability of developing cancer increases dramatically with age. Interestingly, vitamin D deficiency is also recognized more often in people of advanced ages. A potential relationship between vitamin D deficiency and cancer has been reported in the literature.
Method: Review Medline database literature and discuss the relationship between vitamin D status and cancer.
Results: Environmental (including seasonal and geographic) and genetic factors contribute to the development of both vitamin D deficiency and cancer. The vitamin D receptor is present in many tissues, especially in malignant cells, and may contribute to the successful use of vitamin D and its analogs in the treatment of some cancer patients.
Conclusion: Further investigation of the role of vitamin D in the treatment of cancer is warranted.
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| http://dx.doi.org/10.1016/j.critrevonc.2009.04.008 | DOI Listing |
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