Background: The reported incidence of thyroid nodules in children and adolescents is estimated to be between 1% and 2%. However, this incidence may be increasing because diagnostic radiological procedures are detecting incidental thyroid nodules in children. The objective of this study was to assess the diagnostic accuracy, sensitivity, and specificity of ultrasound-guided fine-needle aspiration (US-FNA) of thyroid nodules in children and adolescents.
Methods: Forty-two children (mean age, 14.75 years) underwent US-FNA of 52 thyroid nodules. The specificity, sensitivity, diagnostic accuracy, and unsatisfactory rates were compared to other similar studies.
Results: Six patients had a cytological diagnosis of papillary thyroid cancer, which was confirmed at surgery. There were no false-negative specimens, and cytological diagnostic accuracy was 93.7%. The inadequate rate was only 1.9%.
Conclusions: US-FNA of thyroid nodules in children and adolescents is highly accurate in experienced hands and is associated with a very low inadequate rate.
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http://dx.doi.org/10.1089/thy.2009.0058 | DOI Listing |
AACE Clin Case Rep
September 2024
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
Background/objective: Medullary thyroid carcinoma (MTC) is an uncommon thyroid cancer (TC), rarely found in hyperfunctioning goiter.
Case Report: We present a case of a woman treated for breast carcinoma (BCA) found to have a benign hyperfunctioning nodular goiter, its likely transformation to MTC, and its treatment. Family history revealed papillary thyroid cancer in her nephew.
Arch Pathol Lab Med
December 2024
From the Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (SW Kim, JH Chung, TH Kim).
Context.—: Fine-needle aspiration is an effective tool for sampling thyroid nodules; its results are classified according to the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), whose categories define malignancy risks.
Objective.
World J Surg
December 2024
Monash University Endocrine Surgery Unit, Department of General Surgery, Alfred Hospital, Melbourne, Victoria, Australia.
Background: Despite widespread use of standardized classification systems, risk stratification of thyroid nodules is nuanced and often requires diagnostic surgery. Genomic sequencing is available for this dilemma however, costs and access restricts global applicability. Artificial intelligence (AI) has the potential to overcome this issue nevertheless, the need for black-box interpretability is pertinent.
View Article and Find Full Text PDFSci Data
December 2024
Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, No. 18 Shilongshan Road, Hangzhou, 310024, China.
Thyroid nodules are a common endocrine condition with an increasing incidence over the decades. Data-independent acquisition has been widely utilized in discovery proteomics to identify disease biomarkers and therapeutic targets. To analyze the thyroid disease-related proteome in a high-throughput, reproducible and reliable manner, we introduce thyroid-specific peptide spectral libraries.
View Article and Find Full Text PDFAcad Radiol
December 2024
Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China (M.Z., K.T.). Electronic address:
Rationale And Objectives: The association between hypoechoic halos and thyroid cancer in patients with thyroid nodules remains a contentious issue. The objective of this study was to examine the potential correlation between the thickness of hypoechoic halos and the presence of thyroid cancer in individuals with thyroid nodules.
Methods: The study retrospectively analyzed a cohort of 320 patients with thyroid nodules presenting hypoechoic halos from January 2019 to December 2022.
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