AI Article Synopsis
- Alkoxide C-O bond cleavage happens easily at room temperature when titanium(IV) halide is present.
- The cleavage generates a carbocation that can react with alkynes.
- This reaction efficiently produces trisubstituted (E)-alkenyl halides with a high level of stereoselectivity.
Article Abstract
Alkoxide C-O bond cleavage occurs readily at room temperature in the presence of titanium(IV) halide. Capture of the resultant carbocation by alkynes provides an efficient route to trisubstituted (E)-alkenyl halides with high stereoselectivity.
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| http://dx.doi.org/10.1021/ol900669t | DOI Listing |
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