[Study of cefadroxil and cephradine charge transfer process by fluorescence quenching method].

Guang Pu Xue Yu Guang Pu Fen Xi

Key Laboratory of Coal Science and Technology, Taiyuan University of Technology, Ministry of Education and Shanxi Province, Taiyuan 030024, China.

Published: February 2009

A simple and sensitive fluorescence quenching method was developed for the examination of cefadroxil and cephradine. The method is based on the reaction of fluorescein with cefadroxil or cephradine, resulting in the formation of complexes with weak fluorescence, i.e. quenching the fluorescence intensity of the system. By the use of absorption spectroscopy, infrared spectroscopy and quantum chemistry calculation the reaction process of the cephalosporins and the bonding of reaction mechanism were basically analyzed. Based on this, the fluorescence spectrometry method for the determination of the contents of cefadroxil and cephradine was developed: The maximum excitation and emission wavelength was at 483 nm, and 517 nm and 519 nm respectively. The linear calibration curves were obtained over the cefadroxil and cephradine concentration ranges of 0.3-13.5 mg x L(-1) and 0.1-1.2 mg x L(-1) respectively. The proposed method has been successfully applied to the examination of the subject drugs in its pharmaceutical dosage with good precision and accuracy. The recoveries are 99.63%-99.91% and 99.71%-100.08% respectively.

Download full-text PDF

Source

Publication Analysis

Top Keywords

cefadroxil cephradine
20
fluorescence quenching
12
cephradine
5
fluorescence
5
[study cefadroxil
4
cephradine charge
4
charge transfer
4
transfer process
4
process fluorescence
4
quenching method]
4

Similar Publications

Article Synopsis
  • Tuberculosis (TB) is a significant global health issue, and repurposing existing antimicrobial drugs could enhance treatment options, specifically through the use of beta-lactams in conjunction with beta-lactamase inhibitors.* -
  • This study tested seven beta-lactams and two inhibitors for their effectiveness against Mycobacterium tuberculosis and identified that clavulanate significantly boosted the beta-lactam activity compared to avibactam, leading to avibactam's exclusion from further tests.* -
  • The research found various combinations of beta-lactams that worked synergistically with clavulanate, while most combinations with second-line TB drugs like moxifloxacin showed negative interactions, highlighting the importance of careful drug pairing
View Article and Find Full Text PDF

Importance: and contribute to global health challenges by forming biofilms, a key virulence element implicated in the pathogenesis of several infections.

Objective: The study examined the efficacy of various generations of cephalosporins against biofilms developed by pathogenic and .

Methods: The development of biofilms by both bacteria was assessed using petri-plate and microplate methods.

View Article and Find Full Text PDF

Antimicrobial agents are essential to protect human and animal health. During the coronavirus disease 2019 pandemic, antimicrobials such as cephalosporins were widely used as prophylactics and to prevent bacterial co-infection. Undoubtedly, the prevalence of antibiotics in the aquatic environment will ultimately affect the degree of resistance against these bacteria in animals and the environmental systems.

View Article and Find Full Text PDF

In present study, eleven cephalosporin drugs were selected to explore their new medically important enzyme targets with inherited safety advantage. To this end, selected drugs with active ingredient, cefpodoxime proxetil, ceftazidime, cefepime, ceftriaxone sodium, cefaclor, cefotaxime sodium, cefixime trihydrate, cephalexin, cefadroxil, cephradine, and cefuroxime, were evaluated and found to have significant activity against urease (IC50 = 0.06 ± 0.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!