Objective: To study the triterpenoid saponins in Hemsleya chensnsis.
Method: The chemical constituents were isolated and purified by various chromatographic methods and their structures were elucidated on the basis of spectral analysis.
Result: Seven known triterpenoid saponins were isolated from the root of H. chensnsis and were identified as 3-O-beta-D-glucuropyranosyl-oleanol-icacid (1), 3-O-beta-D-glucopyra-noside-oleanolicacid-28-O-beta-D-glucopyranoside (2), 3-O-(6'-methylester)-beta-D-glucuropyranosyl olea- nolic acid-28-O-alpha-L-arabinopyranoside (3), 3-O-(6'-methylester)-beta-D- glucuropyranosyl- oleanolic acid-28-O-beta-D-mannupyranoside (4), 3-O-(6'-ethyl ester)-beta-D-glucuropyranosyl oleanolic acid-28-O-beta-D- glucopyranoside (5), 3-O-alpha-L-arabinopyranoside-(1-->3) -beta-D-glucuropyranosyl- oleanolic acid-28-O-beta-D-glucopyranoside (6), 3-O-beta-D-glucu-ropyranosyl-oleanolic acid-28-O-beta-D-glucopyra-noside-(1-->6)-beta-D-glucopyranoside (7).
Conclusion: Compounds 1-7 were isolated from this plant for the first time.
Download full-text PDF |
Source |
---|
Phytomedicine
January 2025
Traditional Chinese Medicine Hospital of Meishan, Meishan 620010, China. Electronic address:
Background: Mitochondrial dysfunction plays a crucial role in the development of a variety of diseases, notably neurodegenerative disorders, cardiovascular diseases, metabolic syndrome, and cancer. Natural saponins, which are intricate glycosides characterized by steroidal or triterpenoid structures, have attracted interest due to their diverse pharmacological benefits, including anti-inflammatory, antiviral, and anti-aging effects.
Purpose: This review synthesizes recent advancements in understanding mitochondrial dysfunction and explores how saponins can modulate mitochondrial function.
PLoS One
January 2025
Wuzhou University, College of Food and Pharmaceutical Engineering, Guangxi, P. R. China.
Ginsenosides are the most important secondary metabolites of ginseng. Ginseng has developed certain insect resistance properties during the course of evolutionary environmental adaptation. However, the mechanism underlying the insect resistance of ginseng is poorly understood.
View Article and Find Full Text PDFJ Cosmet Dermatol
January 2025
Cosmetic Research Center, School of Chemical and Material Engineering, Jiangnan University, Wuxi, China.
Background: Excessive lipogenesis of the skin triggers some dermatological concerns, such as enlarged pores, acne, and blackheads. Although topical drug treatments can offer temporary relief, their prolonged usage may lead to side effects of dryness, irritation, or allergic reactions. Consequently, the development of safer and efficacious ingredients in cosmetics for managing sebum overproduction represents a significant yet challenging endeavor.
View Article and Find Full Text PDFRapid Commun Mass Spectrom
April 2025
Department of Traditional Chinese Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Rationale: Panax quinquefolius L. (PQ), a commonly used traditional Chinese medicine and a food, is usually processed into various products, including white PQ, red PQ (two- or three-time steamed PQ), and black PQ (nine-time steamed PQ). Previous studies demonstrated that volatile components (VOCs) were the important active substances of PQ, which had antibacterial, antiviral, and anti-leukemia activities.
View Article and Find Full Text PDFPhytochemistry
January 2025
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:
Previously undescribed triterpenoid saponins (1-8), along with eight previously reported analogues (9-16), were isolated from an EtOAc extract obtained from the roots of Rubus setchuenensis. Structures were established based on HRESIMS, 1D and 2D NMR, as well as by literature comparisons. All compounds were isolated for the first time from the genus Rubus.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!